Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight

Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight in the China Health and Nutrition Survey (CHNS)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03281512

Enrollment

14383

Registered

2017-09-13

Start date

1989-01-01

Completion date

2012-12-31

Last updated

2024-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes, Hypertension, Morality, Overweight

Keywords

Saturated fatty acids, CHNS

Brief summary

The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The investigators aim to use the data from the China Health and Nutrition Survey to assess the long-term association of SFAs intake with total mortality, diabetes, hypertension and overweight.

Detailed description

The role of saturated fatty acids (SFAs) intake in the development of total death, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is lacking.The investigators aim to utilize the data from the China Health and Nutrition Survey. The investigators will calculate the cumulative average intake of SFAs based on 3 consecutive 24-h dietary recalls in each round.Sex-specific Cox regression models will be used to estimate the relative risk.Results from our work will be used to provide epidemiological evidence for improving recommendation on SFAs intake for Chinese in dietary guidelines.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Adults aged ≥20 with complete data on diet and follow-up time

Exclusion criteria

* Cardiovascular diseases * Diabetes (for analyses of diabetes) * Body mass index ≥ 24 kg/㎡ (for analyses of overweight) * Hypertension (for analyses of hypertension)

Design outcomes

Primary

Measure	Time frame	Description
Mortality	From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years	Incidence of all-cause death, on basis of household members' report
Diabetes	From entry into the study (baseline: 1997-2009) until 2011	Incidence of diabetes, on basis of self-reported physician diagnosis, fasting plasma glucose ≥ 7.0 mmol/l or HbA1c ≥ 6.5%

Secondary

Measure	Time frame	Description
Saturated fatty acids intake	From entry into the study (baseline: 1997-2009) until 2011	Cumulative average intake of saturated fatty acids on basis of 3 consecutive 24-h dietary recalls
Hypertension	From entry into the study (baseline: 1997-2009) until 2011	Incidence of hypertension, on basis of self-reported physician diagnosis, systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg
Overweight	From entry into the study (baseline: 1997-2009) until 2011	Incidence of overweight, on basis of body mass index (BMI), BMI ≥ 24 kg/㎡

Outcome results