Acute Respiratory Distress Syndrome
Conditions
Keywords
ARDS, Esophageal pressure, Mechanical ventilation
Brief summary
This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.
Interventions
OTHERStrategy 1
PEEP titration according to transpulmonary-end-expiratory pressure
OTHERStrategy 2
PEEP titration according to chest wall elastance measurement
Sponsors
University Hospital, Angers
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age\> 18 years * Moderate or severe ARDS * Consent to participation obtained from a relative
Exclusion criteria
* Protect adult * Pregnant or breastfeeding woman * No-affiliation to the social security scheme * Contra-indication to the placement of an esophageal pressure measuring catheter * Pneumothorax * Hemodynamic and / or respiratory instability * Extra-corporeal membrane oxygenation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Short-term effects of 2 PEEP titration strategies on gas exchange | 2 hours 15 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Short-term effects of 2 PEEP titration strategies on respiratory mechanics | 2 hours 15 min |
| Short-term effects of 2 PEEP titration strategies on hemodynamics | 2 hours 15 min |
Countries
France
Contacts
Primary ContactStudy Official is required by the WHO and BELONCLE, Ass.Pr
Outcome results
None listed