Liver Failure, Acute on Chronic, Liver Injury
Conditions
Keywords
pre-acute-on-chronic liver failure, hepatitis B
Brief summary
The definition and diagnostic criteria of Acute-on-chronic liver failure (ACLF) has been well established by EASL CANONIC study. However, patients with high risk to develop ACLF has not been determined, yet. The aim of current study is to establish a preliminary pre-ACLF definition, and to demonstrate the corresponding risk factors.
Interventions
OTHERstandard treatment
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
1. Chronic hepatitis B virus infection; 2. Any of the followings: Alanine aminotransferase (ALT)≥3 upper limit of laboratory reference (ULN); Aspartate aminotransferase (AST)≥3 ULN; Serum bilirubin≥2 ULN; Acute decompensation (ascites, hepatic encephalopathy, variceal hemorrhage and/or bacterial infections)
Exclusion criteria
1. Previous decompensation; 2. those who had hepatocellular carcinoma or other types of malignancies; 3. those who combined with severe chronic extra-hepatic disease; 4. pregnant; 5. received liver transplantation or kidney transplantation before or after admission; 6. readmission; 7. death within 24 hours.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 28-day ACLF progression | 28-day | progressed to EASL defined ACLF |
| 28-day mortality | 28-day | death within 28-day |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 90-day mortality | 90-day | death within 90-day |
Outcome results
None listed