Effects of Welding Fumes Components
Conditions
Keywords
welder, airport agent, Welding fumes
Brief summary
Metals and oxydes are found in welding fumes and are thought to participate in increasing cardiovascular risk in exposed workers. Investigators aimed to evaluate the impact of this occupational exposure on cardiovascular system in a highly exposed population, ship repairing welders and to compare this population to paired controls.
Detailed description
In an exposed-non-exposed study, investigators will include 30 welders and 30 airport runway agents for control. As part of cardiovascular independent risk factors, microvascular endothelial function will be evaluated directly by laser Doppler flowmetry. Blood samples will be also collected and circulating markers of endothelial function (VW factor, E-selectin, VCAM, ICAM, circulating DNA), inflammation (CRP, IL-1β, IL-8, TNFα, IL-10), platelet activation (procoagulant microparticles, thrombin generation, fibin monomer) will be measured. A complete clinical and functional cardiovascular status will be documented in every participant.
Interventions
DIAGNOSTIC_TESTLaser doppler, blood tests, and holter ECG
Diagnostic tests : * laser doppler * blood tests * Holter ECG. No drug and no placebo were used in this arm.
Sponsors
University Hospital, Brest
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male or Female ≥ 18 years * Employee performing welding or airport operations * free, informed and written consent * Being affiliated to a social security system
Exclusion criteria
* Taking cardiovascular medications which modify endothelial function and / or coagulation (antiplatelet, antihypertensive, cardiotropic). * People with a history of ischemic cardiovascular disease, thrombotic disease, chronic inflammatory disease * Pregnant women * People with health status would be likely, in the baseline state, to have parameters studied in the study disrupted.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular reactivity | 1 day | Assessement of microvascular reactivity by laser Doppler flowmetry associated to iontophoretic administration of ACh and SNP |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Coagulation activation | 1 day | Assessment of markers of blood coagulation |
| vascular inflammation | 1 day | Assessment of factors of inflammation |
| Impregnation of metals activation | 1 day | Assessment of impregnation factor |
| Oxidative stress activation | 1 day | Assessment of markers of oxidative stress |
Countries
France
Outcome results
None listed