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Feasibility of a Cytokine Expression Profile in Immune Cells as an Orientation Tool in Therapeutic Decisions for Auto-inflammatory and Auto-immune Diseases

Feasibility of a Cytokine Expression Profile in Immune Cells as an Orientation Tool in Therapeutic Decisions for Auto-inflammatory and Auto-immune Diseases

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03280797
Acronym
IL-MAI
Enrollment
44
Registered
2017-09-13
Start date
2017-11-24
Completion date
2022-01-12
Last updated
2022-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid Arthritis

Brief summary

This study will assess the feasibility of using cytokine expression profiles in blood samples as a method for evaluating rheumatoid polyarthritis

Interventions

PROCEDUREBlood sample

2ml blood taken into TruCulture tube

Sponsors

Centre Hospitalier Universitaire de Nīmes
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan * Patient is at least 18 years old * Subjects included as patients have rheumatoid polyarthritis according to ACR EULA 2010, DAS28\>3.2 criteria * Subjects included as controls are healthy volunteers who have no overexpression of cytokines

Exclusion criteria

* The subject is participating in an interventional study, or is in a period of exclusion determined by a previous study * The subject refuses to sign the consent * It is impossible to give the subject informed information * The patient has had at least 3 months of specific treatment that can potentially impact cytokine profile

Design outcomes

Primary

MeasureTime frameDescription
Dosage of cytokines between groupsDay 0Concentration measured by ELISA and flow cytometry

Secondary

MeasureTime frameDescription
Creation of biobankDay 0Storage of blood samples

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026