Validation of Progranulin as a Biomarker for Sepsis

Sensitivity and Specificity of Progranulin as a Biomarker for Sepsis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03280576

Acronym

PROGRANULIN

Enrollment

556

Registered

2017-09-12

Start date

2015-04-30

Completion date

2019-06-30

Last updated

2019-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

Postoperative, Dysfunction Following Cardiac Surgery

Brief summary

Progranulin blood concentrations in patients with sepsis will be analysed in relation to disease status in order to validate progranulin as a biomarker for sepsis. Patients undergoing cardiac surgery will serve as controls.

Detailed description

Single nucleotide polymorphisms with known effects on Progranulin plasma concentrations will be assessed in a separate analysis. Expression levels of microRNAs isolated from plasma, circulating exosomes and blood cells will be determined by next-generation sequencing to characterize epigenetic influences on progranulin plasma levels.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Sepsis or Septic Shock defined according to SEPSIS-3 criteria - Age \> 18 years

Exclusion criteria

* No informed consent * Age \< 18 years * Pregnancy * Immunosuppression (including transplantation) * Charlson Comorbidity Index \> 0 (healthy volunteers)

Design outcomes

Primary

Measure	Time frame	Description
Change in progranulin plasma concentrations during ICU - therapy	ICU admission, day 1, day 4 of ICU therapy	Blood samples will be taken at the abovementioned time points

Secondary

Measure	Time frame	Description
Change in miRNA expression levels in exosomes, serum and blood cells during ICU - therapy	ICU admission, day 1, day 4 of ICU therapy	Blood samples will be taken at the abovementioned time points

Countries

Germany

Outcome results