Obesity, Morbid, Pancreatic Insufficiency
Conditions
Brief summary
Main proposed benefit of sleeve gastrectomy is loss of ghrelin secreting tissue. Some studies express that ghrelin augment pancreatic regeneration. Therefore we hypothesized that with sleeve gastrectomy it may result with pancreatic insufficiency.
Detailed description
Mechanism of weight loss differs in bariatric surgery according to type of surgery. With sleeve gastrectomy which has restrictive mechanism, ghrelin excretion decreases, and this condition is attributed as an additional mechanism in weight loss. Ghrelin effects pancreatic regeneration, and loss of ghrelin may result with pancreatic insufficiency. Therefore we aimed to deteremine this association.
Interventions
PROCEDURESleeveGastrectomy
Preoperative enzyme test before and after sleeve gastrectomy. Sleeve Gastrectomy will be performed. Preoperative (in one month) and Postoperative (after 3 months) pancreatic enzyme sufficiency (with steatocrit or fecal elastase) will be compared.
Sponsors
Umraniye Education and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Patients underwent bariatric surgery (Sleeve gastrectomy) after concordonce with NIH criteria
Exclusion criteria
Additional operations to sleeve gastrectomy like duodenal switch. Other bariatric operations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pancreatic excorine enzyme difference | post operative 3 months | Effect of operation on pancreatic excorine enzyme |
Countries
Turkey (Türkiye)
Contacts
Primary ContactFatih Basak, MD
Outcome results
None listed