Effects of Brain Network by Simultaneous Dual-mode Stimulation in Subacute Stroke Patients

Investigation for Individualized Noninvasive Neuromodulation in Neurorehabilitation of Brain Disease: Longitudinal Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03279640

Enrollment

Registered

2017-09-12

Start date

2014-03-01

Completion date

2017-02-28

Last updated

2017-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Motor Disorder, Stroke

Keywords

Motor Network, Resting-state fMRI, Repetitive Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation

Brief summary

Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of stroke patients' motor function by altering the cortical excitability. Recently, more challenging approaches, such as stimulation of two or more sites or use of dual modality have been studied in stroke patients. In this study, simultaneous stimulation using both rTMS and tDCS (dual-mode stimulation) over bilateral primary motor cortices (M1s) was investigated to compare its modulatory effects with single rTMS stimulation in subacute stroke patients.

Detailed description

Investigators assessed each patient's motor function using the Fugl-Meyer Assessment (FMA) score and acquired their resting-state fMRI (rs-fMRI) data at two times: prior to stimulation and 2 months after stimulation. Changes in rs-fMRI network measures were investigated between groups.

Interventions

DEVICErTMS on ipsilesional M1

DEVICEtDCS on contralesional M1

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* First-ever stroke patients * Subacute stage (less than 4 weeks) * Total Fugl-Meyer Assessment (FMA) score under 84

Exclusion criteria

* Major active neurological disease or psychiatric disease * A history of seizure * Metallic implants in their brain

Design outcomes

Primary

Measure	Time frame	Description
Neuroimaging Assessment	Change from baseline resting-state brain network at 8 weeks after intervention	Resting-state fMRI

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 25, 2026