Iodine Deficiency, Nutritional Requirements
Conditions
Keywords
Iodine, Balance experiment, EAR, Chinese women, Euthyroid
Brief summary
A 4-week study was conducted in 25 Chinese euthyroid women. Unified diets with different iodine contents (cooked with non-iodized salt or iodized salt) were provided in two different periods. The total iodine intake from diet, water and air as well as the total iodine excretion by urine, faces and respiration were monitored and determined, and a total of 300 samples were collected. The sweat iodine loss was also considered. Moreover, the regression curve model between the 24-h iodine intake and 24-h iodine excretion was also established.
Detailed description
The experiment was conducted between November and December with a total duration of 1 month. Referring to the experience from Harrison and Dworkin, however, considering the negative iodine balance reported, during the first 3 weeks, the diet was provided with non-iodized salt, while the diet with iodized salt was only offered in the last week. The total daily iodine intake consisted of dietary iodine intake, water iodine intake and iodine from breathing, while iodine could be excreted out of human body by urine, faces, sweat and breathing. The 24-h iodine intake and 24-h iodine excretion were determined in each individual participant, and the iodine balance was calculated accordingly.
Interventions
DIETARY_SUPPLEMENTiodized table salt, non-iodized table salt
During the first 3 weeks, the diet was provided with non-iodized salt, while the diet with iodized salt was only offered in the last week.
Sponsors
Tianjin Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Participants received a diet with iodized table salt or non-iodized table salt
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* The ones with normal thyroid function, urinary iodine concentration, agree with the experiment.
Exclusion criteria
* The ones with abnormal thyroid hormone level, urinary iodine concentration (UIC) or autoantibody-positive were excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total iodine intake and total iodine excretion | 12 days | Iodine intake includes iodine from food, water and air (μg/d). |
| Total iodine excretion | 12 days | Iodine excretion includes iodine excreted by urine, feces, sweat and breath (μg/d). |
| urinary iodine concentration (UIC) | At the beginning of the experiment | μg/L |
| Thyroid function | At the beginning of the experiment | FT3 (pmol/L), FT4 (pmol/L),TSH (mIU/L), TG (ng/mL), TGAb (IU/mL), TPOAb (IU/mL) |
Outcome results
None listed