Arthroscopic Guided Synovial Biopsies

Diagnosis of Temporomandibular Joint Arthritic Disease Using Arthroscopic Guided Synovial Biopsies

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03279016

Enrollment

Registered

2017-09-12

Start date

2018-05-31

Completion date

2019-12-31

Last updated

2018-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temporomandibular Arthritis

Brief summary

To detect accuracy of serology in diagnosis of temporomandibular joint arthritis.

Detailed description

According to a search of previously published studies on accuracy of serology no sensitivity or specificity data was found regarding accurate detection of arthritis through serology, hence the aim of this study is to detect accuracy of serology in diagnosis of temporomandibular joint arthritis.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients suffering from TEMPOROMANDIBULAR JOINT ARTHRITIS. * Patients should be free from any systemic disease that may affect normal healing and predictable outcome. * Patients who will agree to the consent

Exclusion criteria

* Patients with any systemic disease that may affect normal healing. * Pregnant females. * Patients with acute infection. * Patients with bony ankyloses. * Patients with risk of tumor dissemination.

Design outcomes

Primary

Measure	Time frame	Description
accuracy of serology	2 years	To determine the sensitivity or specificity of serology in diagnosis of temporomandibular joint arthritis

Secondary

Measure	Time frame	Description
C-reactive protein	2 years	To be measured in a blood sample with (mg/dL) unit where Normal CRP levels are below 3.0 mg/dL.
Anti-Cyclic Citrullinated Peptide	2 years	To be measured in a blood sample with (titre-AU)
ANA	2 years	To be measured in a blood sample with binary outcome (positive or negative)
Rheumatoid factor	2 years	To be measured in a blood sample with (IU/mL) unit as The normal reference range for RF is less than 15 IU/mL
Cellular population- type	2 years	Presence of inflammatory cells infiltrate at the synovial membrane biopsy : \- type of cells
Cellular population- number of cells	2 years	Presence of inflammatory cells infiltrate at the synovial membrane biopsy: \- mean number of cells
HLA-B27	2 years	To be measured in a blood sample with binary outcome (positive or negative)

Countries

Egypt

Contacts

Primary ContactAHMED EISSA, MASTER

drahmedadel75@gmail.com+201147700383

Outcome results