Hypertrophic Cardiomyopathy
Conditions
Keywords
hypertrophic cardiomyopathy, implantable cardioverter defibrillator, positron emission tomography
Brief summary
The overall rationale is to reduce the risk of sudden cardiac death in individuals with hypertrophic cardiomyopathy (HCM). The novel approach of this study is to correlate Positron Emission Tomography (PET) findings to ventricular arrhythmias detected by the implantable cardioverter defibrillator (ICD). This could potentially lead to an improved risk stratification of HCM patients.
Detailed description
Positron Emission Tomography (PET) is a functional imaging technique that utilizes radioactive tracers to gain information on physiological or pathophysiological processes in vivo. Different tracers can provide information on different processes of interest. In cardiology, metabolic processes consuming oxygen (aerobic) can be studied with 11-Carbon-Acetate, sympathetic innervation can be studied with 11-Carbon-hydroxyephedrine and using 15-Oxygen-water the myocardial blood flow. Structural information of the heart such as left ventricular mass, left ventricular volumes and wall thickness can also be calculated with PET. The aim is to correlate PET parameters and burden of ventricular arrhythmias in order to improve risk stratification in HCM.
Interventions
DIAGNOSTIC_TESTPositron Emission Tomography
Positron Emission Tomography
Sponsors
Landstinget i Värmland
Dalarna County Council, Sweden
Uppsala University Hospital
Region Gävleborg
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Hypertrophic cardiomyopathy, implantable cardioverter defibrillator, informed consent
Exclusion criteria
* Patients younger than 18 years, pregnancy, breast feeding, claustrophobia, intolerance/allergic reaction to adenosin or mannitol, severe hypotension, unstable angina pectoris, incompensated systolic heart failure, increased intracranial pressure, hypovolemia, dipyramidole.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ventricular tachycardia (VT) vs ejection fraction | History of VT since receiving an implantable defibrillator within last 15 years | Ventricular tachycardia vs positron emissions tomography parameter ejection fraction (EF) |
| Ventricular tachycardia (VT) vs myocardial blood flow | History of VT since receiving an implantable defibrillator within last 15 years | Ventricular tachycardia vs positron emissions tomography parameter Myocardial blood flow (MBF) |
| Ventricular tachycardia (VT) vs mass | History of VT since receiving an implantable defibrillator within last 15 years | Ventricular tachycardia vs positron emissions tomography parameter mass |
| Ventricular tachycardia (VT) vs wall thickness | History of VT since receiving an implantable defibrillator within last 15 years | Ventricular tachycardia vs positron emissions tomography parameter wall thickness |
| Ventricular tachycardia (VT) vs oxygen consumption | History of VT since receiving an implantable defibrillator within last 15 years | Ventricular tachycardia vs positron emissions tomography parameter oxygen consumption (MVO2) |
| Ventricular tachycardia (VT) vs sympathetic innervation | History of VT since receiving an implantable defibrillator within last 15 years | Ventricular tachycardia vs positron emissions tomography parameter sympathetic innervation (retention index) |
| Ventricular tachycardia (VT) vs myocardial external efficiency | History of VT since receiving an implantable defibrillator within last 15 years | Ventricular tachycardia vs positron emissions tomography parameter myocardial external efficiency (MEE) |
| Ventricular tachycardia (VT) vs stroke work | History of VT since receiving an implantable defibrillator within last 15 years | Ventricular tachycardia vs positron emissions tomography parameter stroke work (SW) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Atrial fibrillation (AF) vs myocardial blood flow | History of VT since receiving an implantable defibrillator within last 15 years | Atrial fibrillation vs positron emissions tomography parameter myocardial blood flow |
| Atrial size vs ventricular tachycardia | History of VT since receiving an implantable defibrillator within last 15 years | atrial diameter, volume vs ventricular tachycardia |
| Atrial fibrillation (AF) vs ejection fraction | History of VT since receiving an implantable defibrillator within last 15 years | Atrial fibrillation vs positron emissions tomography parameter ejection fraction (EF) |
| Atrial fibrillation (AF) vs mass | History of VT since receiving an implantable defibrillator within last 15 years | Atrial fibrillation vs positron emissions tomography parameter mass |
| Atrial fibrillation (AF) vs wall thickness | History of VT since receiving an implantable defibrillator within last 15 years | Atrial fibrillation vs positron emissions tomography parameter wall thickness |
| Atrial fibrillation (AF) vs oxygen consumption | History of VT since receiving an implantable defibrillator within last 15 years | Atrial fibrillation vs positron emissions tomography parameter oxygen consumption (MVO2) |
| Atrial fibrillation (AF) vs sympathetic innervation | History of VT since receiving an implantable defibrillator within last 15 years | Atrial fibrillation vs positron emissions tomography parameter sympathetic innervation (retention index) |
| Atrial fibrillation (AF) vs myocardial external efficiency | History of VT since receiving an implantable defibrillator within last 15 years | Atrial fibrillation vs positron emissions tomography parameter myocardial external efficiency (MEE) |
| Atrial fibrillation (AF) vs stroke work | History of VT since receiving an implantable defibrillator within last 15 years | Atrial fibrillation vs positron emissions tomography parameter stroke work (SW) |
Countries
Sweden
Contacts
Primary ContactPeter Magnusson, MD
Backup ContactJonny Nordström, MSc
Outcome results
None listed