CMT1A, CMT - Charcot-Marie-Tooth Disease, Hereditary Peripheral Neuropathy, Peripheral Neuropathy
Conditions
Keywords
Physiotherapy, Physical therapy, Balance, Posturography
Brief summary
A cross-sectional study which will look at the effects of AFO's and vibrating insoles on balance performance in people with CMT disease.
Detailed description
Balance impairments and falls are more common in people who have Charcot Marie Tooth disease (CMT) than in people without the condition. CMT is a condition which affects the nerves causing a variety of symptoms including sensation impairments and weakness. The impairments are usually most evident in the feet and hands, but they can progress very slowly moving closer to the trunk. Ankle Foot Orthoses (AFO's) are often prescribed to help with walking and daily function. So far the effects of AFO's on standing balance in people who have CMT have not been looked at. Insoles are also often prescribed to realign foot deformity and reduce pain. Insoles which give a vibratory input have had a positive impact on walking in older people but have not been looked at in balance and in CMT. Insoles which give a vibration feedback to the sole of the foot when worn have been designed. This study will look at whether the use of AFO's and the vibratory insoles have an effect on standing balance in people with CMT or related peripheral neuropathy. Balance measurements will be taken in a single session comparing a variety of postures. Patients will be recruited from neurology outpatient clinics at the National Hospital of Neurology and Neurosurgery.
Interventions
None listed
Sponsors
University College London Hospitals
St George's, University of London
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Clinical or genetically confirmed diagnosis of CMT or related peripheral neuropathy 2. Mixed sensory and motor presentation 3. Over 18 years 4. Able to stand unsupported for five minutes 5. Able to walk for 50m with or without a walking stick or orthotic devices
Exclusion criteria
1. Presence of other significant neurological disorders (such as multiple sclerosis, cerebrovascular diseases, epilepsy, movement disorders), or major comorbidities (e.g. vestibular dysfunction, use of medication which may affect balance, cognitive impairment, presence of medical conditions in which exercise training may be detrimental). 2. Presence of peripheral neuropathy caused by a condition other than CMT. 3. Limb surgery during the six months prior to screening (or planned before final assessment). 4. Women of child-bearing age if they are pregnant, planning a pregnancy during their time in the study or in the 12 weeks following giving birth. This is due to the effects of pregnancy on balance.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Posturography | 30 second caputer in a variety of conditions | CODA motion movement analysis for postural sway Measures will be taken in all conditions with feet together and feet apart. Both conditions will also be looked at with eyes open and eyes closed. |
| force measures | 30 second caputer in a variety of conditions | AMTI forceplate for centre of pressure . Measures will be taken in all conditions with feet together and feet apart. Both conditions will also be looked at with eyes open and eyes closed. |
Countries
United Kingdom
Contacts
Primary ContactMagdalena Dudziec
Backup ContactGita Ramdharry
Outcome results
None listed