Iron Metabolism Disorders
Conditions
Brief summary
Analyzed iron status, HFE mutations and ethnicity for women in five primary care centers in the United States and Canada using de-identified data from the HEIRS study.
Detailed description
HEIRS included a cross-sectional screening study of 101,168 patients, 25 years of age or older, in the primary care setting. Participants were recruited from four centers in the U.S .and one in Canada from February 2001 to February 2003. We will evaluate results for women aged 25-44 years of age who are self-reported as Asian, Black, Hispanic or White. The lower detection limit for the serum ferritin (SF) assay in the HEIRS study was 15 μg/L and therefore the definition of iron deficiency will be SF concentration ≤ 15 μg/L. Elevated SF concentrations, possibly indicative of elevated iron stores, will be classified by two definitions: 1) SF concentration \> 300 μg/L and 2) SF \>200 μg/L in combination with TSAT \>45%. Proportions will be compared by Pearson's chi-square. Logistic regression models will be used to identify independent associations with measures of iron deficiency and elevated iron stores.
Interventions
OTHERobservation
observation
Sponsors
Weill Medical College of Cornell University
Victor Gordeuk
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 44 Years
Inclusion criteria
1. primary care women included in the HEIRS study with in the age range of this study 2. Self designation as Asian American, African American, Hispanic American or White.
Exclusion criteria
1. Age \>44 years 2. Self-described ethnicity other in than inclusion criterion 2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Elevated serum ferritin | One measurement was made at the time of recruitment and this is the measurement that will be analyzed. | Serum ferritin \>300 ug/L |
| Elevated serum ferritin and transferrin saturation | One measurement was made at the time of recruitment and this is the measurement that will be analyzed. | Serum ferritin \>200 ug/L and transferrin saturation \>45% |
| Iron deficiency | One measurement was made at the time of recruitment and this is the measurement that will be analyzed. | Serum ferritin \<15ug/L |
Countries
United States
Outcome results
None listed