Physical Activity
Conditions
Brief summary
This study will investigate whether manipulating resistance exercise frequency impacts muscle protein synthesis rates. The investigators will test the hypothesise that a higher resistance exercise frequency will result in greater muscle protein synthesis rates than a lower resistance exercise frequency.
Detailed description
Resistance exercise is currently the most effective means of building or maintaining muscle mass. Resistance exercise guidelines generally suggest that those looking to increase muscle mass should train each muscle group once to twice per week. However, it has been proposed that it may be of greater benefit to train a muscle group with a higher frequency (i.e., four to six times per week) than currently suggested. If true, completing the same total volume of resistance exercise in more frequent, smaller bouts could prove to be a more beneficial strategy to optimally build or maintain muscle mass. Therefore, this study will investigate whether manipulating resistance exercise frequency impacts cumulative muscle protein synthesis rates in young individuals. Participants will undergo a 7 day period of habitual activity before completing the same total volume of resistance exercise as either; i) one isolated bout (low frequency) or ii) five smaller bouts (high frequency) over a period of 7 days.
Interventions
BEHAVIORALLow Frequency Condition
Young, untrained participants complete 7 days of habitual physical activity followed by a 7 day period where participants complete a single bout of unilateral resistance exercise.
BEHAVIORALHigh Frequency Condition
Young, untrained participants complete 7 days of habitual physical activity followed by a 7 day period where participants complete the same total volume of resistance exercise as the low frequency condition as five smaller bouts of unilateral resistance exercise.
Sponsors
Maastricht University
University of Birmingham
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index (18.5-29.99 kg/m2) * Untrained - defined as: Perform activities of daily living and recreation but have completed no regular lower body resistance-type exercise (e.g., weight training) activity in the last year. * Good general health
Exclusion criteria
* Lidocaine allergy * Hypertension (≥140/90 mmHg) * Current participation in another clinical study * Previous participation in this study * Bleeding disorder/s * Current or recent smoker * Vegetarian or vegan * Past history of substance abuse and/or taking prescription or non-prescription medication (e.g., beta-blockers, insulin or thyroxine) or supplements that may influence normal metabolic responses.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in muscle protein synthesis (FSR %/day) | At day 10 and 15. | The change in muscle protein synthesis rates (FSR %/day) from baseline will be determined between the low and high frequency conditions at days 10 and 15 using deuterium oxide (D2O). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in satellite cell response | At day 10 and 15. | The change in acute satellite cell response will be determined in muscle samples following low and high frequency resistance exercise at days 10 and 15. |
Countries
United Kingdom
Outcome results
None listed