Age-related Cognitive Decline, Alzheimer Dementia, Mild Cognitive Impairment, Neurocognitive Disorder, Vascular Dementia
Conditions
Keywords
Subjective cognitive decline, Mild Cognitive Impairment, Dementia, Cerebral aging
Brief summary
The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment.
Detailed description
The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment, and in particular the biomarkers that predict cognitive and functional decline. Comprehensive profiling of each subject is performed through a multi-domain assessment protocol including detailed demographics, lifestyle factors, neuropsychological battery, mood, MRI, genetics, blood biomarkers, and other patient-centred parameters including level of disability, quality of life and societal engagement. Ongoing annual follow up captures the essential clinical events and changes in neurocognitive function (conversion to MCI or dementia), mood, level of disability and quality of life; as well as repeat blood tests. The HKU NCD Cohort is the first-ever Asian dementia cohort to be formally included into the Dementia Platforms UK, achieving an international collaborative status with other UK-based cohorts. The study neuropsychological battery is aligned with the NACC UDS3 battery.
Interventions
DIAGNOSTIC_TESTNeurocognitive battery
Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted). NACC: Story recall, Benson's complex figure copy, colour trail test (black & white), verbal fluency, digit forward and backward span.
DIAGNOSTIC_TESTMRI
MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients
BIOLOGICALBlood tests
Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis
DIAGNOSTIC_TESTEEG with event-related potential (ERP)
128-channel EEG with ERP for Go/NoGo and Prospective Memory (PM) tasks for selected patients
DIAGNOSTIC_TESTAmyloid PET CT
F18 Flutametamol PET CT for selected patients
Sponsors
Dementias Platform UK
The University of Hong Kong
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Older adults with or without neurocognitive disoder. HKU NCD Cohort focuses primarily on people with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).
Exclusion criteria
* Severe Parkinson's disease, major depressive disorder or severe psychiatric conditions, significant communication difficulties (e.g. aphasia, deafness), terminal cancer or likely end-of-life in the next 12 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive decline | 1 year | Change in total HK-MoCA score between baseline and follow-up |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Functional decline | 1 year | Change in Lawton's IADL score between baseline and follow-up |
| Neuropsychiatric decline | 1 year | Change in Neuropsychiatric Index (NPI) between baseline and follow-up |
| Quality of life decline | 1 year | Change in QoL-AD score between baseline and follow-up |
| Change in cognitive impairment status | 1 year | Progression to mild cognitive impairment (MCI) or dementia status |
Countries
Hong Kong
Contacts
Primary ContactJoseph SK Kwan, MD
Backup ContactCharlene Cheng, BA
Outcome results
None listed