Chronic Postoperative Pain
Conditions
Keywords
Chronic pain, CPSP, Dexmedetomidine, Surgery
Brief summary
Chronic postoperative pain (CPSP) is common symptom in patients after surgery, seriously affected the quality of life. Accumulating evidences have demonstrated dexmedetomidine can improve chronic pain. However, the prevention of dexmedetomidine on CPSP remain uncertain.
Detailed description
Chronic postoperative pain (CPSP) is defined as pain persisting at least 3 months after surgery. It is most common in patients who undergoing breast or thoracic surgery. Dexmedetomidine, a adrenergic α2 agonists, can alleviate the postoperative pain 24 h after surgery. In our study, patients were randomly assigned to one of the two group to receive 0.5mg/kg/h infusion dexmedetomidine (Group D, n=57) or normal saline (Group C, n=57). The pain scales were evaluated day 1, day 2, day 3, month 3, month 6 after surgery.
Interventions
DRUGsaline
an equal volume of saline
DRUGdexmedetomidine
dexmedetomidine, 0.5ug/kg/h by intravenous infusion, intraoperative
Sponsors
Zhongda Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Intervention model description
paitents undergoing breast or thoracic surgery
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients must have been 18 to 65 yr old, and been scheduled for breast or thoracic surgery.
Exclusion criteria
* Patients with limitations of self-expression or visual dysfunction or having emergency surgery, a severe psychiatric illness, or chronic pain problems in the chest area for longer than 2 months before the surgery,or patients who could not provide informed consent were excluded. * Pregnant women and prisoners were also excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the pain intensity measure | 12 months | Self reported pain intensity in rest and activity will be recorded at day 1 before sugery, month 3, month 6, month 12 after sugery. The intensity of pain was measured by numeric rating scale (0=no pain, 10=worst possible pain) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| anxiety | 12 months | The anxiety will be self reported by patents at day 1 before surgery, month 3, month 6, month 12 after surgery.The anxiety will be scored by a Visual Analogue Scale of anxiety (0=no anxiety, 10=worst possible anxiety) |
| depression | 12 months | The depression will be evaluated at day 1 before surgery, month 3, month 6, month 12 after sugery by a questionnaire |
| sleep disturbance | 12 months | Sleep disturbance will be evaluated at day 1 before surgery, month 3, month 6, month 12 after sugery by questionnaires. |
Countries
China
Contacts
Primary ContactYang Jian-jun, PhD
Backup ContactWang Xing-ming
Outcome results
None listed