Bladder Cancer
Conditions
Keywords
chemoradiation for, T1G3 BC
Brief summary
To evaluate the short term results of chemoradiation in case of T1G3 BC after BCG failure.
Detailed description
Non- muscle invasive bladder cancer (NMIBC) is a heterogeneous group of cancers. For most urologists the treatment of T1G3 tumor poses a dilemma of management.The spectrum of clinical behavior includes; T1 lesions that will not progress however T1G3 may be potentially lethal, associated with metastatic disease at the time of presentation. The major goal of treatment for T1G3 BC should be bladder preservation whenever possible. Intravesical therapy with Bacille Calmette Guerin (BCG) may decrease the recurrence rate by compared with transurethral resection of bladder tumor (TURBT) alone.
Interventions
COMBINATION_PRODUCTchemoradiation
chemoradiation in case of T1G3 BC after BCG failure.
Sponsors
Assiut University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients with recurrent T1G3 bladder cancer after 6 doses of BCG consenting for chemoradiation and refusing radical cystectomy
Exclusion criteria
* Any patients with distant metastasis or positive LN on CT or MRI. * Patients unfit for chemoradiation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Result of chemoradiation for recurrentT1G3 BC after BCG failure | followup within two years | treatment of 20 patients with recurrent T1G3 BC by chemoradiation to see efficacy and safety .and to reduce the number of recurrent cases and improve survival. |
Contacts
Primary Contactmoktar dawood
Backup ContactDiaa El Din Mohamed
Outcome results
None listed