The Use of Cyanoacrylate on Palatal Wound

The Efficacy of Cyanoacrylate on Palatal Wound Healing and Postoperative Complaints

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03273010

Enrollment

Registered

2017-09-06

Start date

2015-12-31

Completion date

2016-12-31

Last updated

2017-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival Recession

Brief summary

The palatal donor site of autogenous free gingival grafts significantly influences the patient's morbidity. The purpose of this study was to evaluate the efficacy of cyanoacrylate on palatal wound healing and postoperative complaints.

Detailed description

A total of 35 patients were included in the study. In the test group (19 patient), cyanoacrylate was placed over the palatal wounds; conversely, the 16 control group patients were allowed to heal in a conventional way without cyanoacrylate. Primary bleeding time, presence of secondary bleeding, postoperative pain and completion of epithelization were assessed following free gingival graft operation. As a result, compared to the control group it was determined that the cyanoacrylate tissue adhesive could reduce the postoperative morbidity and improve the wound healing.

Interventions

PROCEDUREFree gingival graft

Free gingival graft was harvested from palatal donor site

PROCEDURECyanoacrylate application

Periacyrl was applied on palatal wounds

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* no systemic diseases * no coagulation disorders * no drug intake in the previous 6 months that might effect the periodontal health status * no pregnancy or lactation * no smoking habit * \<1 mm attached gingiva width on one or two lower anterior teeth * Miller Class I- II- III (Miller 1985) with deep gingival recession (˃ 3mm)

Exclusion criteria

* Hematologic disorders * No cooperation

Design outcomes

Primary

Measure	Time frame	Description
Primary bleeding time	baseline	The moment of active blood flow stasis that a clinical photograph could be taken by examiner without need for suction.

Secondary

Measure	Time frame	Description
Visual Analog Scale (VAS)	1-7 days after operation	The changes in postoperative pain level after the operation
Analgesic consumption	1-7 days after operation	The changes in the number of painkiller taken to relieve pain after the operation
Completion of epithelization	Once a week for a month after the operation	The epithelization assessed by the peroxide test

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026