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Active Choice in the EHR to Promote Statin Therapy

Using Active Choice in the EHR to Promote Cardiologists to Prescribe Evidence-Based Statin Therapy

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03271931
Enrollment
23066
Registered
2017-09-05
Start date
2018-09-24
Completion date
2019-06-05
Last updated
2019-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases

Brief summary

Cardiovascular (CV) events are the leading cause of mortality in the United States. Statins have been demonstrated to be an effective tool for reducing CV events and mortality, but statins are often either not prescribed or under-prescribed for patients that meet evidence-based guidelines. In this study, we will evaluate a health system initiative using active and passive choice prompts in the electronic health record to prompt cardiologists to prescribe evidence-based statin therapy. In partnership with the health system, this will be conducted as a randomized, controlled trial to evaluate its effect.

Detailed description

This study will use a randomized, controlled trial to evaluate a health system initiative. Cardiologists randomly assigned to the control arm will receive no interventions. For cardiologists randomly assigned to the active choice intervention, the electronic health record will be used to prompt cardiologists to initiate or change statin therapy for patients not on evidenced-based guidelines based on the 2013 American College of Cardiology / American Heart Association (ACC/AHA) and the National Lipid Association (NLA) through a best practice alert in Epic which appears on the screen and forces a decision before the clinician can move on. For cardiologists randomly assigned to the passive choice intervention, the electronic health record will be used to create a passive alert using the same evidence-based guidelines. The passive alert will not block clinician workflow and instead will be available in the background for the cardiologist to open and then use to make a prescribing decision. The intervention period will be 6 months in duration.

Interventions

BEHAVIORALActive choice

EHR alert prompting cardiologists to make an active choice to prescribe a statin or not.

BEHAVIORALPassive choice

EHR passive alert to cardiologists about prescribing a statin

Sponsors

University of Pennsylvania
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Have a cardiologist at the University of Pennsylvania Health System * Meets 2013 ACC/AHA or NLA guidelines for statin prescription

Exclusion criteria

* Allergy to statins * Severe renal insufficiency defined as glomerular filtration rate (GFR) less than 30 mL/min or on dialysis * Adverse reaction to statins including a) myopathy, b)rhabdomyolysis, c)hepatitis * Pregnant * On a PCSK9 Inhibitor medication

Design outcomes

Primary

MeasureTime frameDescription
Change in the percent of eligible patients prescribed statin therapy at a dose that meets evidence-based guidelines6 MonthsAmong patients not on guideline-based statin dosages, the percent that are prescribed guideline-based therapy at appropriate dose.

Secondary

MeasureTime frameDescription
Change in percentage of eligible patients prescribed a statin, at any dose.6 MonthsAmong patients not on a statin, the percent that are prescribed guideline-based therapy, at any dose.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 17, 2026