Apnoeic Oxygenation
Conditions
Keywords
Apnoeic oxygenation, Airway management, Oxygen insufflation, Paediatric general anaesthesia
Brief summary
Airway management is a core clinical skill in anaesthesia. Pre-oxygenation prior to induction of anaesthesia is standard practice to prevent desaturation. Apnoeic oxygenation in adults is effective and prolongs the time to desaturation. The effectiveness of apnoeic oxygenation in the adult is well document, however evidence in the paediatric is lacking. Therefore, the aim of this study was to investigate the effectiveness of apnoeic oxygenation during airway management in children. This was a pilot randomised controlled trial. Patients were randomised to either receive apnoeic oxygenation or standard care during the induction of anaesthesia. The primary outcome was the duration of safe apnoea, defined as a composite of the time to first event, either time for SpO2 to drop to 92% or time to successfully secure the airway, and the lowest SpO2 observed during airway management. Secondary outcomes were number of patients whose SpO2 dropped below 95% and number of patients whose SpO2 dropped below 92%.
Interventions
DEVICEApnoeic oxygenation
3 L/min of oxygen by nasal cannula during as apnoeic oxygenation during airway management.
Sponsors
King Abdullah International Medical Research Center
Cardiff University
University of Birmingham
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
1 Years to 8 Years
Healthy volunteers
No
Inclusion criteria
* Patients were included who were scheduled for elective surgery under general anaesthesia. * Age: one eight years old. * ASA I and II only. * Patients with normal cardiorespiratory function.
Exclusion criteria
* Children undergoing dental surgeries in which nasal intubation is needed. * Patients who suffered from quick drops in oxygen saturation more rapidly than healthy children due to different reasons such as: respiratory and pulmonary diseases, active or recent upper respiratory tract infection, syndromes with cardiopulmonary pathologies, cardiac anomalies, anaemia, depressed respiratory effort, ventilation/perfusion imbalance, Obstructive Sleep Apnoea (OSA), and airway obstruction. * Patients reported with nasal obstruction. * Patients with grades of laryngoscopic view (Cormack Lahane) greater than II, which indicates upper airway obstruction.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to first event | Estimated: 10 seconds to 3 minutes | Time to first event: either time for SpO2 to fall to 92% or time to successfully secure the airway as usual practice without allowing desaturation |
| The lowest SpO2 observed during airway management | Estimated: 10 seconds to 3 minutes | The lowest SpO2 observed during airway management |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients whose SpO2 dropped below 95% | Estimated: 10 seconds to 3 minutes | Number of patients whose SpO2 dropped below 95% |
| Number of patients whose SpO2 dropped below 92% | Estimated: 10 seconds to 3 minutes | Number of patients whose SpO2 dropped below 92% |
Outcome results
None listed