Doppler Sonography of Cerebral Blood Flow for Early Prognostication After Out-of-hospital Cardiac Arrest

Doppler Sonography of Cerebral Blood Flow for Early Prognostication After Out-of-hospital Cardiac Arrest: the DOTAC Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03270683

Acronym

DOTAC

Enrollment

Registered

2017-09-01

Start date

2016-05-02

Completion date

2017-10-31

Last updated

2019-12-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest

Keywords

Out-of-hospital cardiac arrest, transcranial Doppler sonography, cerebrovascular circulation, prognosis

Brief summary

Objective: To assess neurologic prognostication by early Transcranial Doppler Sonography (TCD) in comatose survivors after cardiac arrest. Design: Prospective study between May 2016 and November 2017 in a medical intensive care unit and cardiac intensive care unit in a university hospital. Patients: all comatose patients older than 18 years successfully resuscitated from an out-of-hospital cardiac arrest (OHCA). Patients for whom OHCA is associated with traumatic brain injury, no window for TCD measurements, or dead before neurological prognostication are excluded.

Detailed description

The investigators measure the pulsatility index (PI) and diastolic flow velocity (DFV) of the right and left middle cerebral artery during the first 12 h after return of spontaneous circulation (ROSC). The highest value of DFV and the lowest of PI will use for the statistical analysis. Cerebral Performance Category evaluate neurologic outcome at hospital discharge. Data provided by early TCD after ROSC are associated with neurological outcome. The use of these data could lead to the development of therapeutics improving cerebral perfusion in patient resuscitated from an OHCA.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* older 18 years * out-of-hospital cardiac arrest with recovery of spontaneous cardiac activity

Exclusion criteria

* transcranial doppler not done or not interpretable * associated cranial trauma * died without neurological assessment

Design outcomes

Primary

Measure	Time frame	Description
Evaluate the relation between TCD measurements and neurologic outcome at hospital discharge	6 months	Good score = CPC 1-2 and bad score = CPC 3-5

Secondary

Measure	Time frame	Description
Measurement of pulsatility index	12 hours	Evaluate the association between pulsatility index and period of cardiac arrest
Entry of doppler parameters	6 months	Identify a doppler parameter than can improve the neurological outcome

Countries

France

Outcome results