Healthy
Conditions
Brief summary
The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men
Detailed description
Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.
Interventions
OTHERexercise training
subjects complete 4-5 weeks of training
Sponsors
Morten Hostrup, PhD
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy * VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD) * Body mass index (BMI) of 19-26 kg/m2 * Normal ECG (electrocardiography)
Exclusion criteria
* Serious adverse effects to exercise * Chronic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skeletal muscle proteome signature | Change from baseline proteome signature at 5 weeks | proteomics |
Other
| Measure | Time frame | Description |
|---|---|---|
| Skeletal muscle acetylome signature | Change from baseline acetylome signature at 5 weeks | acetylomics |
| Skeletal muscle mitochondrial respiration | Change from baseline at 5 weeks | Mitochondrial respiratory capacity |
| Maximal oxygen uptake | Change from baseline at 5 weeks | Maximal oxygen uptake |
Countries
Denmark
Outcome results
None listed