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Fertility and Ovarian Reserve Function in the Patient With Inflammatory Bowel Disease

Fertility and Ovarian Reserve Function in the Patient With Inflammatory Bowel - a Cross-sectional Survey and Case Control Study

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03269916
Enrollment
80
Registered
2017-09-01
Start date
2017-05-01
Completion date
2018-08-01
Last updated
2017-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility Disorders, Ovarian Reserve Function, Pregnancy Outcomes

Brief summary

ECCO consensus, the fertility would decline in activity inflammatory bowel disease(IBD), because of anus lesions and pelvic abscess, or who underwent surgery, especially in patients with ileal pouch anal anastomosis (IPAA) storage.The study on fertility in inflammatory bowel disease were almost epidemiological investigation, the lack of objective evaluation of fertility, and controversial.This study will explore the fertility, ovarian reserve function and the pregnancy outcomes in patients with IBD.

Interventions

OTHERAnti Mueller hormone

used to assess ovarian reserve parameters

OTHEREstrogen

used to assess ovarian reserve parameters

OTHERFollicle-Stimulating Hormone

used to assess ovarian reserve parameters

OTHERAntral alveolar cell count

used to assess ovarian reserve parameters

Sponsors

Sixth Affiliated Hospital, Sun Yat-sen University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE

Eligibility

Sex/Gender
FEMALE
Age
17 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

1. Inflammatory bowel disease 2. 17-40 years old 3. female

Exclusion criteria

1. in pregnancy or lactation 2. a drug that has been or is being used known to affect ovarian function, such as cyclophosphamide 3. reproductive system diseases unrelated to disease or treatment of inflammatory bowel disease, such as hysterectomy, pelvic radiotherapy after surgery, after ovariectomy, polycystic ovary syndrome, endometriosis, ovarian granulosa cell tumor 4. other endocrine diseases, such as prolactin, hyperthyroidism, lead to endocrine disorders; 5. malignant tumor

Design outcomes

Primary

MeasureTime frameDescription
The AMH of IBD patients is lower than that of healthy women1 monthAMH is used to assess ovarian reserve function
The E2 of IBD patients is lower than that of healthy women1 monthE2 is used to assess ovarian reserve function
The FSH of IBD patients is lower than that of healthy women1 monthFSH is used to assess ovarian reserve function
The AFC of IBD patients is lower than that of healthy women1 monthAFC is used to assess ovarian reserve function

Countries

China

Contacts

Primary Contactxiang peng, MM
stefaniepx@163.com18302076916

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026