Diabetes Mellitus Type 2 With Hyperglycemia, Periodontitis
Conditions
Keywords
uncontrolled type 2 diabetes mellitus, periodontitis, non surgical periodontal treatment, vitamin C
Brief summary
Periodontitis patients with uncontrolled type 2 diabetes mellitus will receive non-surgical periodontal treatment and then be supplemented with daily 500 mg vitamin C (test group) or placebo (control group) for 2 months. Clinical parameters will be retrieved at baseline, at the end of week 4 and at the end of week 8.
Interventions
DRUGVitamin C 500 MG Oral Capsule
non surgical periodontal treatment+vitamin C 500 mg/day for 2 months
OTHERplacebo
non surgical periodontal treatment+placebo for 2 months
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* uncontrolled type 2 diabetes mellitus * periodontitis
Exclusion criteria
* complications from diabetes mellitus, e.g., renal insufficiency * receive insulin * diseases that interfere with wound healing, e.g., HIV * receive one of the followings: tetracycline, acetaminophen, NSAID, warfarin, aluminum-containing antacids, barbiturates, phenobarbital, pentobarbital, secobarbital, hormone replacement therapy, chemotherapeutic drug, protease inhibitor * receive other vitamins or antibiotics within 6 months * smoking * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sulcus bleeding index | baseline, change from baseline sulcus bleeding index at 4 weeks, change from baseline sulcus bleeding index at 8 weeks | bleeding upon probing of gingival sulcus from the most severe periodontitis tooth |
Countries
Thailand
Contacts
Primary ContactPiyapat Kunsongkeit, DDS
Backup ContactSupanee Rassameemasmaung, DDS, M.Sc (Periodontics), Ph.D
Outcome results
None listed