Biomarkers, Heparin-Induced Thrombocytopenia, Thrombosis
Conditions
Keywords
Heparin-induced thrombocytopenia, Thrombosis, thrombin-antithrombin, d-dimer, Thrombelastograghy
Brief summary
Heparin induced thrombocytopenia (HIT) is a kind of catastrophic thrombotic complications after the application of heparin. If HIT without treatment, death rate is as high as 30% to 50%. Early diagnosis of HIT and prevention of thrombosis is very important. This study is planned to assess the use of thrombotic biomarkers in patients with HIT, including thrombin-antithrombin complex, d-dimer, fibrin degradation products and Thrombelastograghy monitoring . These biomarkers are monitored in 5-14 days post-operation to assess the risk of thrombosis in HIT patients. All patients were followed up for 30 days, and clinical outcomes, including new thrombus and death, were recorded during follow-up.
Interventions
DIAGNOSTIC_TESTHIT with thrombosis
Testing thrombin-antithrombin complex, d-dimer, fibrin degradation products and Thrombelastograghy.
Sponsors
Wuhan Asia Heart Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Hospitalized patients undergoing cardiac surgery. * Receiving unfractionated heparin anticoagulation.
Exclusion criteria
* history of heparin-induced thrombocytopenia * pregnant woman
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Thrombotic event | 30 days | New thrombosis, including deep venous thrombosis,pulmonary embolism,Cerebral infarction,superior mesenteric artery embolism,artery embolism etc. |
| Deaths | 30 days | All-cause deaths |
Contacts
Primary ContactQingkun Fan, MD
Outcome results
None listed