Clinical Assessment of New Treatment Regimen for Adult Fulminant Myocarditis

Conditions

Fulminant Myocarditis

Keywords

Fulminant Myocarditis, Retrospective cohort study

Brief summary

This is a retrospective cohort study to assess the clinical outcome of patients with fulminant myocarditis using Life-support Based Comprehensive Treatment Regimen and conventional therapy. In the present study, participants receive various treatment as part of routine medical care without any assignment of specific interventions to them. The process of treatment during hospitalization were recorded in medical chart and was reviewed by independent research personnel.

Wu He, Junfang Wu, Dongxue Wang, Wendong Chen, Yongcui Yan et al. (16 authors)

Journal of Advanced Research2025-06-012 citations

10.1016/j.jare.2025.06.005

The clinicopathologic features of fulminant myocarditis

Guanglin Cui, Jiali Nie, Huihui Li, Luyun Wang, Kun Miao et al. (8 authors)

Journal of Advanced Research2025-06-011 citations

10.1016/j.jare.2025.06.040

Soluble ST2 Is a Sensitive and Specific Biomarker for Fulminant Myocarditis

Jin Wang, Mengying He, Huihui Li, Yanghui Chen, Xiang Nie et al. (22 authors)

Journal of the American Heart Association2022-04-0437 citations

10.1161/jaha.121.024417

Expert consensus statement on the diagnosis and treatment of fulminant myocarditis in the context of the COVID-19 pandemic

O. Sh. Oynotkinova, О. М. Масленникова, В. Н. Ларина, Elena V. Rzhevskaya, Andrei V. Syrov et al. (14 authors)

Academy of medicine and sports2020-12-184 citations

10.15829/2712-7567-2020-2-13

1137A life support based comprehensive treatment regimen dramatically lowers the in-hospital mortality of patients with fulminant myocarditis —- a multiple center study

Chunying Chen, Shaoqiu Li, Guanglin Cui, Ning Zhou, Jiaqi Jiang et al. (6 authors)

European Heart Journal2019-10-01

10.1093/eurheartj/ehz748.0006

Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis.

Wang D, Li S, Jiang J, Yan J, Zhao C, Wang Y, Ma Y, Zeng H, Guo X, Wang H, Tang J, Zuo H, Lin L, Cui G, Section of Precision Medicine Group of Chinese Society of Cardiology, Editorial Board of Chinese Journal of Cardiology, Working Group of Adult Fulminant Myocarditis.

2018-12-0381 citations

10.1007/s11427-018-9385-3

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* 16 years of age or older; * Diagnosed as fulminant myocarditis: * Evidence of myocarditis on biopsy or increased biomarkers of myocardial injury (TNI and CK-MB and BNP or NT-pro-BNP); * Acute onset of symptoms of cardiac dysfunction: dyspnea, palpation, chest pain, and/or syncope; * Image for cardiac injury: marked diffused reduction in left ventricle wall movement, with dramatically decreased left ventricle ejection fraction (LVEF) \< 45%; * Cardiogenic shock, e.g., systolic blood pressure ≤90 mmHg or mean arterial pressure \< 70mm Hg or a systolic blood pressure decrease \> 40 mm Hg, which is associated with the signs of hypofusion: cyanosis, cold extremities, oliguria, and/or changes in mental status.

Exclusion criteria

* Also considering acute coronary syndrome but unable to perform coronary angiography to distinguish acute coronary syndrome from fulminant myocarditis; * Myocardial injury caused by sepsis, chemotherapeutical agents, or poisons; * Unstable hemodynamics or shock caused by hypovolemia.

Design outcomes

Primary

Measure	Time frame	Description
death or cardiac transplantation	through hospital discharge, an average of 10 days	The occurrence of death or cardiac transplantation was determined through direct contact with the patient or the family of the patient or review of the patient's medical record.

Countries

China

Contacts

Primary ContactYang Sun, MD candidate

d201578301@hust.edu.cn86-27-83663280

Outcome results