Atrophic Maxilla, Ridge Preservation
Conditions
Keywords
leucocyte- and platelet rich fibrin, ridge preservation, growth factors, platelet concentrates
Brief summary
A split-mouth design study will be performed regarding the use of platelet concentrates on ridge preservation: L-PRF vs A-PRF vs control. Patient needing multiple teeth extractions in the upper jaw (single-rooted teeth) will be recruited. The use of each platelet concentrate or control will be randomized by means of a computer program. The results will be analysed clinical and radiographically (CBCT). When the subject will choose for implant rehabilitation, a biopsy will be taken in the site of the preserved sockets. The region will be localized with a customized stent, fabricated with the position of the extracted teeth. VAS scales will be provided to evaluate the post-operative discomfort.
Interventions
OTHERL-PRF
Platelet concentrates are produced from a small peripheral blood sample, which is immediately centrifuged without any anticoagulant. Coagulation starts during the centrifugation, and three layers are obtained: red blood corpuscles (RBCs) at the bottom of the tube, platelet-poor plasma (PPP) on the top and an intermediate layer called buffy coat where most platelets and leucocytes are concentrated. L-PRF has potential advantages, namely: it creates a bioactive construct that stimulates the local environment for differentiation and proliferation of stem and progenitor cells and it acts as an immune regulation node with inflammation control abilities, such as slow continuous release of growth factors over a period of 7-14 days.
OTHERA-PRF
Platelet concentrates are produced from a small peripheral blood sample, which is immediately centrifuged without any anticoagulant. Coagulation starts during the centrifugation, and three layers are obtained: red blood corpuscles (RBCs) at the bottom of the tube, platelet-poor plasma (PPP) on the top and an intermediate layer called buffy coat where most platelets and leucocytes are concentrated. L-PRF has potential advantages, namely: it creates a bioactive construct that stimulates the local environment for differentiation and proliferation of stem and progenitor cells and it acts as an immune regulation node with inflammation control abilities, such as slow continuous release of growth factors over a period of 7-14 days.
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* 3 single-rooted teeth needed to be extracted in the upper jaw * patient in good general health as documented by self-assessment * patients must be committed to the study and must be willing to sing the informed consent.
Exclusion criteria
* any systemic medical condition that could interfere with the surgical procedure or planned treatment. * current pregnancy or breast feeding * radiotherapy or chemotherapy in head and neck area * intravenous and oral bisphosphonate * patients smoking \>20 cig/day * unwillingness to return for the follow-up examination
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes horizontal width at crest -1mm | 3 months | Primary outcome variables were defined as the changes in horizontal width at crest-1 mm levels. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes horizontal width at crest -3 mm and 5 mm; vertical resorption; socket fill | 3 months | Changes in horizontal width at crest -3 mm and 5 mm; vertical resorption at the lingual and buccal side; socket fill. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Post-operative scores | 1 week | Post-operative discomfort measured with VAS |
Countries
Belgium
Outcome results
None listed