Obstructive Sleep Apnea, OSAS, Periodontitis
Conditions
Keywords
OSAS, Obstructive Sleep Apnea, Periodontitis
Brief summary
The main objective of this study is to compare the effect of the non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.
Detailed description
There is evidence supporting that OSAS is an independent risk factor for cardiovascular and cerebrovascular diseases such as hypertension, congestive heart failure, myocardial infarction, cardiac-arrhythmia, and stroke.Gender, age, smoking, obesity and diabetes, which are risk factors for periodontitis,It is also common in OSAS at the same time.In addition to common risk factors, both OSAS and periodontitis have been shown to be associated with increased oxidative stress markers. The investigators aimed to investigate whether non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.
Interventions
OTHERExperimental
Experimental: Non-surgical periodontal therapy in patient with OSAS and Periodontitis
OTHERControl
Control: Non-surgical periodontal therapy in Periodontitis
Sponsors
Bezmialem Vakif University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Intervention model description
It's an assessor blinded, parallel group, randomized controlled trial aimed at investigate whether non-surgical periodontal treatment on serum and saliva oxidative stress parameters in patients with periodontitis and obstructive sleep apnea syndrome (OSAS) and in patients with periodontitis only.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* aged ≥18 years old * having more than 16 teeth * BMI\>25 kg/m2
Exclusion criteria
* patients with a history of diabetes mellitus or respiratory diseases * patients who were under any medication that was known to influence periodontal tissues * patients with a history of any periodontal treatment in the past 6 months * patients with hormonal changes such as pregnancy or lactation; and 5) patients having fixed dentures or removable prothesis * OSAS treatment started (using OSAS therapy device or undergoing surgical operation)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Saliva Thiol/disulfid (millimolar per liter (mmol /L)) | 3 months | Changes in serum and salivary oxidative stress parameters |
| Serum Thiol/disulfid (millimolar per liter (mmol /L)) | 3 months | Changes in serum and salivary oxidative stress parameters |
| Saliva Total Antioxidant Status (TAS) level (millimolar per liter (mmol /L)) | 3 months | Changes in serum and salivary oxidative stress parameters |
| Saliva Total Oxidant Status (TOS) level (mikromolar per liter (µmol /L)) | 3 months | Changes in serum and salivary oxidative stress parameters |
| Saliva Oxidative Stress Index (OSI) level : TOS/TAS | 3 months | Changes in serum and salivary oxidative stress parameters |
| Saliva Native Thiol (mikromolar per liter (µmol /L)) | 3 months | Changes in serum and salivary oxidative stress parameters |
| Serum Total Antioxidant Status (TAS) level (millimolar per liter (mmol /L)) | 3 months | Changes in serum and salivary oxidative stress parameters |
| Serum Total Oxidant Status (TOS) level (mikromolar per liter (µmol /L)) | 3 months | Changes in serum and salivary oxidative stress parameters |
| Serum Oxidative Stress Index (OSI) level : TOS/TAS | 3 months | Changes in serum and salivary oxidative stress parameters |
| Serum Native Thiol (mikromolar per liter (µmol /L)) | 3 months | Changes in serum and salivary oxidative stress parameters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gingival Index (GI) | 3 months | Change in clinical measures of chronic periodontitis |
| Bleeding on probing (BOP) | 3 months | Change in clinical measures of chronic periodontitis |
| Clinical attachment loss(CAL) | 3 months | Change in clinical measures of chronic periodontitis |
| Probing pocket depth (PD) | 3 months | Change in clinical measures of chronic periodontitis |
| Plaque Index (PI) | 3 months | Change in clinical measures of chronic periodontitis |
Countries
Turkey (Türkiye)
Outcome results
None listed