Efficacy of Buprenorphine on Postoperative Endodontic Analgesia

Status

Terminated

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03268278

Acronym

EBPEA

Enrollment

Registered

2017-08-31

Start date

2017-04-01

Completion date

2018-07-01

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Keywords

analgesia, endodontic, postoperative

Brief summary

To see whether the addition of buprenorphone to local anesthesia will lengthen postoperative analgesia for endodontic pain

Interventions

DRUGBuprenorphine

Buprenorphine plus local anesthetic

DRUGSterile saline

Placebo 1,8 ml

DRUGlidocaine, epinephrine (Local anesthetic)

2% lidocaine 1:100,000 epinephrine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* persons with preoperative pain to percussion of a tooth with pulpal disease requiring endodontic therapy, healthy individuals, ASA Class I and II, no known allergies to the drugs being administered

Exclusion criteria

* pregnancy, allergy to buprenorphine, allergy to local anesthetic

Design outcomes

Primary

Measure	Time frame	Description
The Efficacy of Buprenorphine in addition to Local Anesthetic in Providing Prolonged Postoperative Endodontic Analgesia	two years	The number of patients with extended postoperative analgesia when compared to the baseline in pain scores on a visual analog scale during a three-day period will be analyzed. A questionnaire containing a visual analog scale and a log for recording the use of rescue analgesics will be used to gather the data.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026