COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old

COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03268109

Acronym

COGITO

Enrollment

281

Registered

2017-08-31

Start date

2017-09-22

Completion date

2025-05-12

Last updated

2025-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Impairment, HIV/AIDS, Memory Impairment

Brief summary

Despite combined antiretroviral therapy (cART), milder forms of HIV-associated neurocognitive disorders (HAND) persist in 20-50% of persons living with HIV (PLHIV). Since more PLH are at risk for HAND due to aging, the frequency of HAND in PLHIV ≥ 65 years old is important to quantify for planning early intervention to attenuate both functional and occupational disabilities due to cognitive impairment.

Interventions

OTHERassessment of cognitive impairment

Measure of Global Deficit Score

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* Personal or familial cognitive complaints * Individual aged ≥ 65 years old and \< 81 years old * Instrumental activities of daily living (IADL) score between 3-4 * French speaking individual * Informed consent signed For PLHIV * HIV infection * Undetectable HIV viral load ≥ 1 year * Current cluster of differentiation (CD4) cell count \> 100/mm3 For controls * negative HIV serology ≤ 6 months

Exclusion criteria

* Opportunistic infection \< 5 years * Contraindications to MRI

Design outcomes

Primary

Measure	Time frame	Description
cognitive impairment	baseline	cognitive impairment frequency, defined by a z-score ≤ 1.65 in at least 2 cognitive domains

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026