Coagulation Disorder
Conditions
Keywords
Bleeding, heart surgery, coagulation, coagulopathy, INR
Brief summary
The investigator is testing blood samples to compare the results of two different techniques. Since blood loss and the need for blood transfusions continue to be major problems after heart surgery and other types of surgery, the blood clotting levels are constantly checked during heart surgery as part of clinical care.The purpose of this study is to compare the INR levels in blood before and after the heart bypass during surgery.
Interventions
DIAGNOSTIC_TESTInternational Normal Ratio (INR)
Blood test for INR using laboratory and point of care methods
Sponsors
University of Miami
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients greater than or equal to 18 years of age. * Patients undergoing elective surgery. * Patients undergoing cardiac surgery. * Patients to undergo general anesthesia with endotracheal intubation. * Patients with well-controlled health disorders.
Exclusion criteria
* Patients currently on Coumadin or other anticoagulants; including, direct thrombin inhibitors and direct Xa inhibitors. * Patients who are under 18 years of age or pregnant. * Patients undergoing emergency surgery. * Patients with known coagulation disorders. * Patients who are unable to provide informed consent in the form of a signature
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in correlation between laboratory and point of care INR | Baseline, Within ten minutes of completion of bypass | Pearson's Coefficient |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in agreement between laboratory and point of care INR | Baseline, Within ten minutes of completion of bypass | Bland-Altman plots |
Countries
United States
Outcome results
None listed