Abortion in First Trimester
Conditions
Brief summary
Recurrent pregnancy loss is classically defined as the occurrence of three or more consecutive pregnancy loss. The American Society of Reproductive Medicine has recently redefined recurrent pregnancy loss as two or more pregnancy losses. A pregnancy loss is defined as a clinically-recognized pregnancy means that the pregnancy has been visualized on an ultrasound or that pregnancy tissue was identified after a pregnancy loss.
Detailed description
Spontaneous pregnancy loss is a surprisingly common occurrence. Whereas approximately 15% of all clinically recognized pregnancies result in spontaneous loss, there are many more pregnancies that fail prior to being clinically recognized. Only 30% of all conceptions result in a live birth. Although no reliable published data have estimated the probability of finding an etiology for recurrent pregnancy loss in a population with 2 versus 3 or more miscarriages, the best available data suggest that the risk of miscarriage in subsequent pregnancies is 30% after 2 losses, compared with 33% after 3 losses among patients without a history of a live birth. This strongly suggests a role for evaluation after just 2 losses in patients with no prior live births. An earlier evaluation may be further indicated if fetal cardiac activity was identified prior to a loss .
Interventions
DRUGProgesterone Suppositories Vaginal
progesterone vaginal suppository
oral progesterone drug
DEVICEdoppler ultrasound
pulsed doppler ultrasound
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
1. pregnant 7-12 weeks documented by pregnancy test &/or ultrasaound. 2. History of at least 2 prior spontaneous abortion before 12 weeks of gestation. 3. Age: 18-35 years 4. Willing and able to give informed consent. 5. Rh +ve patient 6. BMI: 18-32 7. Viable pregnancy through the detection of fetal pulsations by ultrasound 8. Singleton pregnancy 9. Apparently stable pregnancy (no history of vaginal bleeding in this current pregnancy or signs of sac separation in ultrasound)
Exclusion criteria
1. Patients diagnosed to have Anti-phospholipid syndrome or another recognised thrombophilic or autoimmune conditions. 2. Pregnant \> 12 weeks. 3. Contraindication to progesterone use. 4. Diabetic patients, have glucose intolerance. 5. Multiple pregnancies. 6. Thyroid disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of Live births after 28 weeks of gestation | 28 weeks gestation | Live births that survive and continue beyond 28 weeks of gestation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients who Tolerable with the treatment | 12 weeks | efficacy of treatment on patients |
Countries
Egypt
Contacts
Primary ContactAhmed Ibrahim
Backup ContactHesham Abu taleb
Outcome results
None listed