Correlation Between Respiratory Variability of R-R Intervals and Systolic Pressure Variability

Correlation Between Respiratory Variability of R-R Intervals and in Invasive Systolic Blood Pressure During Changes in Posture and Positive End Expiratory Pressure

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03267017

Enrollment

Registered

2017-08-30

Start date

2017-11-01

Completion date

2019-05-01

Last updated

2017-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Rate Determination

Brief summary

This prospective study is designed to assess and quantify the correlation between respiratory changes in R-R interval and the respiratory changed in invasive systolic blood pressure in ventilated patients during changes in posture and peak end expiratory pressure (PEEP) and following a fluid bolus

Interventions

OTHERposture changes

Following induction of general anesthesia and initiation of positive pressure ventilation, patients will be tilted 15 degrees head up for 5 minutes with positive end expiratory pressure of 8 cm H2O, and then 15 degrees head down for 5 minutes with positive end expiratory pressure of 3 cm H2O

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Age 18-80 * Scheduled for surgery under general anesthesia requiring invasive blood pressure monitoring

Exclusion criteria

* Heart Rate other than sinus * Cardiac Pacemaker Status * Transplanted Heart

Design outcomes

Primary

Measure	Time frame
Statistical Correlation between respiratory variability of R-R interval and systolic blood pressure	From immediately after induction of general anesthesia and mechanical ventilation to 20 minutes later

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026