Neoplasms
Conditions
Brief summary
Using the population-based data sources in Iceland and the well-characterized AGES-Reykjavik cohort, our overarching aims are on exploring whether pre-diagnostic serum levels of 25-hydroxyvitamin D (25(OH)D) among older individuals living in Iceland were associated with survival after cancer diagnosis. We also wanted to assess the risk of being diagnosed with cancer in association with 25(OH)D levels. In this population living just south of the arctic circle, vitamin D levels largely depend on dietary- and supplemental sources.
Interventions
None listed
Sponsors
University of Iceland
Icelandic Heart Association
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
66 Years to 98 Years
Healthy volunteers
No
Inclusion criteria
To be part of the AGES-Reykjavik Study, initiated between 2002 and 2006.
Exclusion criteria
Diagnosed with cancer at study entry
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall mortality among cancer patients | Patients were followed from date of diagnosis since 2002 until death or censored at end of the follow-up (December 31, 2014) | We tested the association between pre-diagnostic 25(OH)D levels and total survival |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cancer-specific mortality among cancer patients | Patients were followed from date of diagnosis since 2002 until death or censored at end of the follow-up (December 31, 2014) | We tested the association between pre-diagnostic 25(OH)D levels and cancer survival |
Other
| Measure | Time frame | Description |
|---|---|---|
| Pre-diagnostic 25(OH)D levels and cancer risk | Participants without cancer were followed from the study entry since 2002 until cancer diagnosis, death or end of the observation period whichever occurred first (December 31, 2014) | We tested the association between pre-diagnostic 25(OH)D levels and risk of being diagnosed with cancer |
Outcome results
None listed