Pulmonary Rehabilitation in End-Stage Liver Disease

Does Pulmonary Rehabilitation Improve Frailty and Sarcopenia in End Stage Liver Disease?

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03266575

Enrollment

Registered

2017-08-30

Start date

2018-02-01

Completion date

2024-12-09

Last updated

2024-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End Stage Liver Disease

Keywords

Frailty, Sarcopenia, Pulmonary Rehabilitation

Brief summary

The purpose of this study is to assess the impact of exercise on sarcopenia and frailty. The exercise that will be performed in this study will include either pulmonary rehabilitation or a formal home based video strengthening program

Detailed description

Participants will be randomized into two groups. The Pulmonary Rehabilitation group will undergo exercise under a supervised setting for a total duration of 12 weeks. Patients will perform endurance (treadmill or cycle ergometer), strength (weight resistance) and flexibility training twice a week for a period of an hour per session. Exercises will be supervised by physiotherapists or exercise physiologists. Compliance and performance will be monitored by the trainer. They will receive a pedometer for home use. The Home based program group will perform REST for 10 minutes daily, increasing to 20 minutes daily, after the second week, in their home environment. The total duration of the intervention will be 12 weeks. Patients will be provided with pedometers, REST video and binder, with instructions on how to perform exercises, and resistance bands.

Interventions

BEHAVIORALPulmonary Rehabilitation Exercise

Participants will undergo Pulmonary Rehabilitation exercise. Participants will perform endurance (treadmill or cycle ergometer), strength (weight resistance) and flexibility training twice a week for a period of an hour per session

BEHAVIORALHome Based Exercise

Participants will undergo Home based exercise program consisting of strength and conditioning. Participants will perform REST for 10 minutes daily, increasing to 20 minutes daily, after the second week, in their home environment. The total duration of the intervention will be 12 weeks. Participants will be provided with pedometers, REST video and binder, with instructions on how to perform exercises, and resistance bands.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Intervention model description

randomized to pulmonary rehab vs home based exercise rpogram

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* wait listed for liver transplantation with poor 6 MWT

Exclusion criteria

* age \< 18 years * recent hospitalization (within 14 days) due to decompensation, variceal bleeding in the previous 1 month * large esophageal varices without primary prophylaxis * active excessive alcohol intake (in the previous 3 months) * current overt uncontrolled hepatic encephalopathy * hepatopulmonary syndrome with uncontrolled hypoxia * portopulmonary hypertension * inability to perform exercise * marked symptomatic comorbidities (cardiac, pulmonary, renal).

Design outcomes

Primary

Measure	Time frame	Description
Change in 6 minute walk test	baseline, 3 months	Participants will walk on a straight, flat surface for 6 minutes at a self-determined pace.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026