Epiphora, Ptosis
Conditions
Brief summary
The objective of this study is to investigate quantitative improvement in excessive tearing after administration of Bupivacaine, a local anesthetic, into the affected eyelids.
Interventions
topical anesthetic
Sponsors
McMaster University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Patients age 18 and above, patients with unilateral or bilateral excessive tearing.
Exclusion criteria
Pregnant females, vulnerable populations, patients with severe hepatic disease, or patients using monoamine oxidase inhibitors or tricyclic antidepressants, which are contraindicated with bupivacaine and norepinephrine combinations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline Lacrimal Tear Lake at 6 months | measurements at baseline and 6 months | Measurement of the height (in mm) of the tear film in the lower conjunctival cup de sac, obtained during slit lamp examination of the eye |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline Lid distraction at 6 months | measurements at baseline and 6 months | distance (in mm) that the eyelids can be maximally pulled from the globe |
| Change from baseline Lid snap back at 6 months | measurements at baseline and 6 months | Amount of time (in sec) it takes for the lids to return to their normal anatomical position after being pulled to their maximum excursion with fingers |
Countries
United States
Outcome results
None listed