Gut Microbiota, Metabolic Syndrome
Conditions
Keywords
Blueberry, Diet
Brief summary
There is growing evidence that nutritional intervention with dietary polyphenols can positively modulate the gut microbiota to improve cardiometabolic health. Whether the beneficial effects of blueberries on obesity and the metabolic syndrome can be linked to their potential impact on the gut microbiota and intestinal integrity remains speculative at this time. Moreover, the mechanisms of action underlying health benefits associated to blueberry consumption are still unknown. The investigators are thus proposing to combine the study of metagenomics, transcriptomics and metabolomics to test whether a prebiotic activity of highbush blueberries can play a role in the prevention of obesity-linked metabolic syndrome in a clinical setting.
Interventions
DIETARY_SUPPLEMENT50 g of blueberry powder, taken daily for 8 weeks
Subjects will consume blueberry powder during 8 weeks to test the possible effects of blueberries on gut microbiota composition and on metabolic syndrome parameters.
DIETARY_SUPPLEMENT50g of placebo blueberry powder, taken daily for 8 weeks
Subjects will consume blueberry placebo powder to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and the active treatment (blueberry powder).
Sponsors
Laval University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and premenopause women in good health * Caucasians * At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men * At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L
Exclusion criteria
* Metabolic disorders (hypertension, diabetes, hypercholesterolemia) * Regular use of medication affecting study parameters * Use of natural health product in the last 3 months * Use of antibiotics in the last 3 months * Nicotine users * Allergy or intolerance for blueberries * Blueberry taste aversion * More than 2 alcohol drinks par day * Particular dietary habits (vegetarism, gluten-free diet, cetogenic diet...) * Weight change of more than 5% in the last 3 months * Surgery in the last 3 months or planed during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in plasma insulin/glucose of overweight/obese men and women taking either blueberry powder or placebo blueberry powder | 12 months |
| Changes in plasma lipids/lipoproteins of overweight/obese men and women taking either blueberry powder or placebo blueberry powder | 12 months |
Secondary
| Measure | Time frame |
|---|---|
| Changes in gene expression in overweight/obese men and women taking either blueberry powder or placebo blueberry powder | 3-6 months |
| Changes in metabolites concentration in overweight/obese men and women taking either blueberry powder or placebo blueberry powder | 3-6 months |
| Changes in the gut microbiota composition in overweight/obese men and women taking either blueberry powder or placebo blueberry powder | 3-6 months |
| Changes in blood pressure of overweight/obese men and women taking either blueberry powder or placebo blueberry powder | 12 months |
| Changes in intestinal integrity of overweight/obese men and women taking either blueberry powder or placebo blueberry powder | 12 months |
| Changes in inflammation biomarkers of overweight/obese men and women taking either blueberry powder or placebo blueberry powder | 12 months |
Countries
Canada
Contacts
PRINCIPAL_INVESTIGATORMarie-Claude Vohl
Laval University
Outcome results
None listed