Urinary Incontinence
Conditions
Brief summary
The objective of this study is to determine to effect of additional oral glutamine to Kegel exercises on pelvic floor strength and clinical parameters of urinary incontinence in females with either urinary incontinence (stress and/or urgency) and pelvic prolapse.
Detailed description
Urinary incontinence is a prevalent and costly condition that affects approximately 38% of older community-dwelling women (age\>60 years). Incontinence predisposes patients to other health problems, contributes to depression and social isolation, is a significant source of dependency among the elderly, and is widely cited as a factor in nursing home admissions. Sarcopenia is age-related and is characterized by loss of muscle mass, strength and endurance. There is not only a decrease in the number of muscle fibers, but also atrophy in the remaining ones. Several studies indicate glutamine supplementations lead to better muscle performance by stimulate muscle producing in extremities. Similarly, we assume glutamine supplementation could increase pelvic muscle mass and improve the pelvic floor strength. From this point, using glutamine supplementation may effect positively on stress, urge or mixed incontinence, and pelvic prolapse.
Interventions
DIETARY_SUPPLEMENTfantomalt supplementation
30 g/day fantomalt supplementation for three months
DIETARY_SUPPLEMENTglutamine supplementation
30 g/day glutamine supplementation for three months
Sponsors
Société des Produits Nestlé (SPN)
Istanbul University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
45 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Presence of urinary incontinence and/or pelvic prolapse and/or decreased vaginal muscle strength in gynaecological examination
Exclusion criteria
* Uncontrolled diabetes * Cognitive dysfunction hampering participation in exercise or assessment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pelvic floor muscle strength with dynamometer | 3 months | vaginal dynamometer |
| Pelvic floor muscle strength with digital palpation | 3 months | digital vaginal palpation method |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| general quality of life | 3 months | King's Health Questionnaire (KHQ) |
| 24 hour pad test | 3 months | assessment of the severity of urinary incontinence as determined by the 24-hour pad weight |
| body composition | 3 months | muscle mass assessed by bioimpedance analysis |
| urinary incontinence dairy | 3 months | urinary incontinence dairy |
| degree of prolapse | 3 months | systematic pelvic examination |
| hand grip strength | 3 months | Jamar hand dynamometer |
| quality of life related prolapse | 3 months | Prolapse quality of life (PQOL) questionnaire |
Countries
Turkey (Türkiye)
Outcome results
None listed