Role of Stem Cells, Platelet Rich Plasma in Treatment of Scars

Role of Stem Cells, Platelet Rich Plasma and Combination of Them in Treatment of Scars

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03264573

Enrollment

Registered

2017-08-29

Start date

2016-07-31

Completion date

2017-07-31

Last updated

2017-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrophic Scar

Keywords

Atrophic scar, PRP, ADSCs

Brief summary

The Objectives of this randomized controlled trial aiming to establishing a protocol of post scar revision care and to Study the effect of PRP and/or Adipose derived Mesenchymal Stem cell injection in improvement of atrophic scar after scar revision.

Detailed description

Forty patients with atrophic scar since one to five years including 25 males and 15 females with ages ranging from ten to 35 years with main age of 22.68 will be divided into four groups each included ten patients. One group will be treated with scar revision only (control group or group I), 2nd group will be injected with PRP after scar revision, 3rd group will be injected with ADSCs after scar revision and the 4th group will be injected with a combination of PRP and ADSCs after scar revision. All groups were assisted pre-operative and six months post-operative. Complications, Scar width, Vancouver scar scale (VSS), surgeon assessment scar scale and patient assessment scar scale will be considered the outcome measurements.

Interventions

BIOLOGICALStem cell

after scar revision PRP is injected intradermally, also adipose derived mesenchymal stem cells

DEVICEMSCs

manual separation of platelets rich plasma and undifferentiated mesenchymal stem cells

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

randomized controlled trial

Eligibility

Sex/Gender

ALL

Age

10 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Patient with atrophic scar. * Age group: 5 years up to 35 years. * No previous medications, surgeries or laser therapy.

Exclusion criteria

* Patient with hypertrophic or pigmented scar. * Patient with any blood disease. * Patients with lipodystrophy.

Design outcomes

Primary

Measure	Time frame	Description
Patient satisfaction (Patient Assessment Scar Scale)	6 months	Patient Assessment Scar Scale

Secondary

Measure	Time frame	Description
Doctor satisfaction (Vancouver Scar Scale)	6 months	Vancouver Scar Scale (VSS)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026