Effects of Antimicrobial Photodynamic Therapy on Regeneration of Class II Furcation Lesions

Effects of Antimicrobial Photodynamic Therapy Associated to Biomaterials on Regeneration of Class II Furcation Lesions

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03264118

Enrollment

Registered

2017-08-28

Start date

2017-04-02

Completion date

2018-12-22

Last updated

2023-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Bone Loss, Periodontal Diseases, Periodontitis, Chronic

Keywords

Periodontal Guided Tissue Regeneration, Photochemotherapy

Brief summary

The aim of this study is to evaluate the additional effect of antimicrobial photodynamic therapy regeneration treatment of mandibular furcation lesions when associated to bovine bone and porcine collagen membrane.

Interventions

PROCEDUREScaling and root planing

Furcation treatment by scaling and root planing

DRUGToluidine Blue O

Antimicrobial photodynamic therapy with toluidine blue O (10mg/ml) and red laser.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Intervention model description

Split-mouth design. One side of mouth is test and the other is control side.

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of class II furcation lesion in mandibular 1st and 2nd molars * Mandibular 1st and 2nd molars without caries, erosion or abrasion

Exclusion criteria

* Smoking habit * Pregnancy * Use of antibiotics in the last six months * Periodontal treatment in the last six months * Endodontic lesion * Systemic diseases that impair wound healing

Design outcomes

Primary

Measure	Time frame	Description
Horizontal probing depth	one year	Measured with a periodontal probe (mm). Ideal if 0.
Tomographic Bone filling	One year	Complete filling of furcation defect in tomographic images. Ideal is a radiopaque image similar to neighbor bone.

Secondary

Measure	Time frame	Description
Probing depth	one year	Distance from gingival margin to bottom of sulcus. Measured with a periodontal probe (mm). Ideal if \< 2 mm.
Clinical Attachment Level	one year	Distance from cemento-enamel junction to bottom of sulcus. Measured with a periodontal probe (mm). Ideal if \< 2 mm.
Bleeding on probing	One year	Visual confirmation of bleeding after probing. Ideal if not bleeding.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026