Evaluation of UDP-glucose as a Urinary Biomarker for Early Detection of Cardiac Surgery-associated Pediatric Acute Kidney Injury

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03263325

Enrollment

305

Registered

2017-08-28

Start date

2017-10-25

Completion date

2027-02-01

Last updated

2026-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Brief summary

Acute kidney injury (AKI) is common in children after cardiac surgery with a reported incidence of 20-40%. Pediatric AKI has been found to be associated with important short and long-term adverse outcomes. A major challenge to management of AKI after cardiac surgery and cardiopulmonary bypass is the lack of early diagnostic markers. Current diagnostic criteria for AKI in children relies exclusively on elevation of serum creatinine concentration and oliguria. Both of these markers lack sensitivity and specificity, and result in delayed detection of kidney injury. This study aims to determine if UDP-glucose can be used as a urinary biomarker to detect subclinical acute kidney injury following pediatric cardiac surgery with cardiopulmonary bypass.

Interventions

OTHERDiscarded urine sample

Collection of discarded urine during surgery and following surgery

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 8 Years

Healthy volunteers

Inclusion criteria

* less than or equal to 8 years of age * scheduled for cardiac surgery

Exclusion criteria

* severe pre-existing renal insufficiency

Design outcomes

Primary

Measure	Time frame	Description
AKI	within 72 hours after surgery	development of AKI

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORDouglas Atkinson, MD

Boston Children's Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 20, 2026