Cognitive Training in Patients With MCI Using fMRI

Cognitive Training in Patients With Mild Cognitive Impairment Using fMRI.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03263247

Enrollment

Registered

2017-08-28

Start date

2017-01-02

Completion date

2026-12-31

Last updated

2026-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment

Brief summary

The current project aims to investigate the trajectories of the visual imaging cognitive training (CT) and alphabet search training using fMRI in patients with amnestic mild cognitive impairment (MCI) and healthy elderly controls (HE). MCI patients will be grouped according to biomarkers (PET PIB).

Detailed description

We will include 40 subjects with amnestic mild cognitive impairment (MCI) multiple domain clinical diagnostic, over 60 years old, recruited through the outpatient clinic of University of Sao Paulo General Hospital. We will also include 20 healthy subjects, over 60 years old, recruited in the community. All the participants will be evaluated by neurologists specialized in cognitive neurology and subjected to a neuropsychological assessment. The 40 participants with MCI and 20 healthy subjects will receive 6 sessions of visual imaging training. After this first study, they will receive cognitive training with alphabet search training. This will be a longitudinal study. MCI patients will be grouped according to biomarkers (PET PIB).

Interventions

BEHAVIORALVisual Memory Training

In the first phase of the study all participants will receive visual memory training. In the second phase they will receive alphabetic search training

BEHAVIORALAlphabet search

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

60 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* Portuguese as native and preferred language; A minimum of 4 years of education; MRI-compatible; Right-handed individuals; Normal corrected vision and hearing; Estimated intelligence average or above (≥ 80 IQ);

Exclusion criteria

* History of neurological disorder, severe mental illness; Current untreated alcohol or substance abuse; Medical conditions that compromise in any way the central nervous system; Presence of visual impairment and / or hearing to preclude cognitive testing; Presence of contraindications to MRI exam; Findings in structural MRI that can interfere with the results of the study

Design outcomes

Primary

Measure	Time frame	Description
Results from task performance in functional magnetic resonance imaging (fMRI)	Baseline, after CT, and 12 months later	fMRI behavioral performance

Secondary

Measure	Time frame	Description
Changes in cognitive measures and brain activation	Baseline, after CT e 12 months follow-up	Logical Memory Test I and II, RAVLT I e II, brain activity, generalization tasks

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 25, 2026