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Beverage Hydration Index of Commercial Therapeutic Beverages

Beverage Hydration Index of Three Commercial Oral Rehydration Therapy ORT Beverages

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03262597
Enrollment
46
Registered
2017-08-25
Start date
2017-02-17
Completion date
2017-04-14
Last updated
2018-03-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

fluid balance, dehydration, rehydration, electrolytes, urine

Brief summary

The beverage hydration index (BHI) assesses the hydration potential of any consumable fluid relative to water. The BHI is a relatively new metric. Our purpose was to assess the BHI of beverages never previously tested, including an amino acid-based oral rehydration solution (AA-ORS), a glucose-containing ORS (G-ORS) and a sports drink (SD) compared to water (control).

Detailed description

The Beverage Hydration Index (BHI) was created to assess the degree to which beverages hydrate, by measuring fluid retention after ingesting a 1 liter bolus and comparing it to water. Drinks with carbohydrates and electrolytes would traditionally be expected to score higher on the BHI due to glucose-sodium cotransport at the gut and osmolality approaching isotonicity with blood. One recent study reported that an oral rehydration solution (ORS) scored better than water, but a sports drink did not. No optimal BHI beverage composition has been described, nor has an optimal osmolality. Recently, a hypotonic amino acid-based rehydration beverage was developed to take advantage of amino acid-sodium cotransport, thus obviating the need for carbohydrate. However, the BHI of this beverage has not yet been assessed. The purpose of this investigation was to assess the hydration potential of this novel beverage in comparison to a commercially available carbohydrate-containing sports drink and oral rehydration solution.

Interventions

Subjects will consume enterade, which is an amino acid-based oral rehydration solution.

Subjects will consume Pedialyte

Subjects will consume Gatorade

OTHERWater

Subjects will consume water as the control beverage

Sponsors

Entrinsic Bioscience Inc.
CollaboratorINDUSTRY
Sonoma State University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Intervention model description

Repeated-measures design with generalized latin square arrangement. Each participant will complete 4 separate trials.

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Healthy male or female * Aged 18-35 * BMI 18-27 kg/m2 * No known cardiovascular, renal or metabolic disease * Moderately active * Moderate alcohol use

Exclusion criteria

* Overweight or obese (BMI \>27 kg/m2) * Competitive athletes during competition season * Current or former cardiovascular, renal or metabolic disease * Habitual consumption of alcohol (\>21 units/week) or regular (\>1/week) high (10 units) intake\* * History of psychiatric illness * Actively seeking to gain or lose weight * Currently taking prescribed medication * Example, a 750 ml bottle of wine at 12% ABV contains 0.750 Liters \* 12 = 9 units

Design outcomes

Primary

MeasureTime frameDescription
Beverage hydration index4 hoursbeverage hydration index

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026