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Corneal Endothelial Cell Loss After Phacoemulsification Compared With Extracapsular Cataract Extraction

Corneal Endothelial Cell Loss After Phacoemulsification Compared With Extracapsular Cataract Extraction in Management of Senile Cataract

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03262285
Enrollment
70
Registered
2017-08-25
Start date
2018-07-01
Completion date
2021-01-15
Last updated
2021-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Senile Cataract

Brief summary

the investigators will compare between the endothelial cell loss after phacoemulsification and extracapsular cataract extraction in management of senile cataract

Detailed description

Age related cataract is believed to be the main cause of reversible blindness worldwide and in developing countries. Population-based studies have reported that cataract is responsible for 47.8% to 51% of all global blindness. Several studies compared phacoemulsification and conventional extracapsular cataract extraction regarding several aspects such as postoperative inflammation and visual rehabilitation. studies proved that phacoemulsification has faster rehabilitation ,less astigmatism and better postoperative vision .However, Extracapsular cataract extraction is still the operation of choice in some cataract cases. The normal corneal endothelium is a single layer of uniformly sized cells with a predominantly hexagonal shape. Adult density of approximately 2400 - 3200 cells/mm².The number of cells decreases at about 0.6% per year and neighbouring cells enlarge to fill the space as the cells cannot regenerate.The minimum cell density necessary for adequate function is in the range of 400 to 700 cells/mm2. The effect of cataract surgery on corneal endothelium is an important factor that affects postoperative vision .However, it is accepted all over the world that there is definite loss of some endothelial cells with all techniques of cataract surgery. Previously, cataract surgery caused enormous loss of endothelial cells , but with enhancement of equipment and surgical techniques, cataract surgery today results in 6-14%loss of endothelial cells. Specular microscopy is a noninvasive photographic technique that allows visualization and analysis of corneal endothelium. specular microscopy is used to show cell count and cell shape in the scanned area.

Interventions

PROCEDUREphacoemulsification

removal of cataract using ultrasound waves

PROCEDUREextracapsular cataract extraction

removal of cataract using surgical corneal incision

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
60 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* Cases of senile cataract of both sexes will be included in this study

Exclusion criteria

* Corneal endothelial pathologies such as Fuch's dystrophy * Complicated cataract * Cataract with history of trauma * Coexisting eye pathology

Design outcomes

Primary

MeasureTime frameDescription
percentage of endothelial cell loss5 minutesspecular microscopy will be done to measure the endothelial cell count before and after the intervention to measure the percentage of loss

Secondary

MeasureTime frameDescription
changes in shape of endothelial cell5 minutesspecular microscopy will be done to identify changes in hexagonality of endothelial cells after the intervention

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026