Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections

Efficacy of Topical Benzocaine in Anterior Maxilla: A Randomised Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03261115

Enrollment

100

Registered

2017-08-24

Start date

2017-08-16

Completion date

2017-09-20

Last updated

2017-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

Pain, Benzocaine, Clinical trial

Brief summary

The aim of this randomized controlled trial. is to test the efficacy of topical anesthesia against the use of no topical agent during buccal infiltration in maxillary anterior teeth. The rationale behind this comparison is to evaluate the practical, clinical outcome of not using any topical agent if in fact topical anesthesia does not reduce pain as reported by various studies and if consequently its usage was to be discontinued.

Detailed description

The clinical implication of topical anesthesia and placebo being the same is to not use either of them prior to LA administration in dentistry. This clinical approach has rarely been studied and this study aims to compare the effects of the use of topical anesthesia against the use of no topical agent prior to buccal infiltration in maxillary anterior teeth.

Interventions

PROCEDURENo topical anesthesia

Lack of use of topical anesthesia application prior to infiltration injection intra-orally

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Above the age of 18 * Males and females both * Participants requiring extraction of maxillary anterior teeth * Intact or minimally restored anterior teeth * Patients with American Society of Anesthesiologists physical status of 1 or 2

Exclusion criteria

* Participants with physical American Society of Anesthesiologists physical status of 3 or 4 * Showing signs of inflammation in the area to be injected * Having known allergy to any of the agents used in the study * Used anti- anxiety drugs or sedatives in the past two weeks * Have taken analgesics on the day of data collection

Design outcomes

Primary

Measure	Time frame	Description
Pain score on needle penetration	Immediately	Pain score measured by numeric pain rating scale
Pain score on local anesthesia deposition	Immediately	Pain score measured by numeric pain rating scale

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026