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Efficacy of Injectable Vitamin C on Accelerating Canine Movement: A Clinical Study

Evaluation of the Effect of Local Injected Vitamin C on Accelerating the Orthodontic Movement of Maxillary Canine Impaction: A Clinical Trial

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03260829
Acronym
mesotherapy
Enrollment
12
Registered
2017-08-24
Start date
2014-01-31
Completion date
2015-02-28
Last updated
2017-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Palatally Impacted Canines

Keywords

vitamin C, palatally impacted canines, intraepidermal injection

Brief summary

efficacy of the injectable vitamin C to reduce the time of canine traction

Detailed description

Objective. The purpose of this study is to investigate the role and efficiency of the locally injected vitamin C in the enhancement of the palatally impacted canine movement. Design. Twelve adult patients with unilateral palatally impacted canines were included in this study. The enrolled patients were randomly allocated into the study groups; control group; orthodontic traction and he test group: orthodontic traction enhanced by intraepidermic vitamin C injection. The study duration was 12 months.

Interventions

DRUGvitamin C

25 IU of vitamin C injected intraepidermally for 6-8 visits till eruption achieved

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
15 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* medically free * patient with good to fair oral hygiene (gingivitis may be included) * both sexes were included * unilateral palatally positioned permenant canines * absence of previous orthodontic treatment * absence of supernumerary teeth, odontoms, cysts, traumatic injuries * the α angle within grade II to III

Exclusion criteria

* systemic diseases especially diabetes and bone diseases * pregnant and lactating mothers * Local causes (smoking, mouth breathing, local trauma and periodontitis).

Design outcomes

Primary

MeasureTime frameDescription
rate of tooth movement12 monthsthe achieved movement in millimeters in one year

Secondary

MeasureTime frameDescription
level of alveolar bone12 monthsthe level of the interproximal and facial alveolar bone after orthodontic treatment with or without injection

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026