Cataract, Diabetes Mellitus
Conditions
Keywords
cataract, phacoemulsification, type 2 diabetes mellitus, corneal endothelial cells
Brief summary
This study investigate the change of the corneal endothelial cells in patients with type 2 diabetes after phacoemulsification with intraocular lens implantation.
Detailed description
The investigators do the clinical prospective study including 30 patients with type 2 diabetes and 30 control patients without diabetes scheduled to undergo cataract surgery. The corneal endothelial cell density, variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness(CCT) were recorded at baseline and at 3 months postoperatively.Then, the investigators compared the two sets of data. At last observing the change of the corneal endothelial cells in patients with type 2 diabetes after phacoemulsification with intraocular lens implantation.
Interventions
OTHERspecular microscope
The corneal endothelial cell density, variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness(CCT) were recorded at baseline and at 3 months postoperatively.
Sponsors
Beijing Tsinghua Chang Gung Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
58 Years to 86 Years
Healthy volunteers
No
Inclusion criteria
the experimental group: 1. Clinical diagnosis of cataract 2. Type 2 diabetes mellitus 3. The recent blood glucose control was stable 4. The glycosylated hemoglobin \< 8% The control group: 1. Clinical diagnosis of cataract 2. No history of type 2 diabetes
Exclusion criteria
1. Corneal lesions 2. Anterior inflammation 3. Ocular trauma or surgical history 4. Glaucoma 5. Corneal endothelial cell density \< 1500 / mm squared
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of the corneal endothelial cell density before-after cataract surgery | half year | Comparison of the corneal endothelial cell density before-after cataract surgery，the density is expressed in terms of the number of cells per square millimeter. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of the endothelial cell size before-after cataract surgery | half year | Comparison of the endothelial cell size before-after cataract surgery，the size is measured in square microns. |
| Comparison of the percentage of hexagonal cells before-after cataract surgery | half year | Comparison of the percentage of hexagonal cells before-after cataract surgery,the percentage are expressed as %. |
| Comparison of the central corneal thickness(CCT) before-after cataract surgery | half year | Comparison of the central corneal thickness(CCT) before-after cataract surgery，the thickness is in microns. |
Outcome results
None listed