CMR Exercise Stress Testing in HFpEF

Conditions

Diastolic Heart Failure

Brief summary

Patients of the University Hospital Göttingen with echocardiographic signs for diastolic heart failure and indication for right heart catheterisation will undergo additional diagnostic testing with CMR including exercise stress for detailed evaluation of diastolic dysfunction and tissue characterisation correlating the results with well-established clinical standards.

Backhaus SJ, Schulz A, Lange T, Rösel SF, Schmidt-Schweda LS, Kutty S, Kowallick JT, Treiber J, Rolf A, Sossalla S, Hasenfuß G, Schuster A.

2025-02-03

10.1038/s41598-025-87032-5

Association of Cardiac MRI–derived Aortic Stiffness with Early Stages and Progression of Heart Failure with Preserved Ejection Fraction

Alexander Schulz, Isabel N. Schellinger, Sören J. Backhaus, Ansgar S Adler, Torben Lange et al. (13 authors)

Radiology Cardiothoracic Imaging2024-08-015 citations

10.1148/ryct.230344

Left Atrial Roof Enlargement Is a Distinct Feature of Heart Failure With Preserved Ejection Fraction

Sören J. Backhaus, Anastasia Nasopoulou, Torben Lange, Alexander Schulz, Ruben Evertz et al. (9 authors)

Circulation Cardiovascular Imaging2024-07-0110 citations

10.1161/circimaging.123.016424

Real-time cardiovascular magnetic resonance imaging for non-invasive characterisation of heart failure with preserved ejection fraction: final outcomes of the HFpEF stress trial

Sören J. Backhaus, Alexander Schulz, Torben Lange, Lennart S. Schmidt-Schweda, Ruben Evertz et al. (8 authors)

Clinical Research in Cardiology2024-01-0313 citations

10.1007/s00392-023-02363-5

Hemodynamic force assessment by cardiovascular magnetic resonance in HFpEF: A case-control substudy from the HFpEF stress trial.

Backhaus SJ, Uzun H, Rösel SF, Schulz A, Lange T, Crawley RJ, Evertz R, Hasenfuß G, Schuster A.

2022-11-2116 citations

10.1016/j.ebiom.2022.104334

Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction

Sören J. Backhaus, Torben Lange, Elisabeth F. George, Kristian Hellenkamp, Roman Johannes Gertz et al. (16 authors)

Circulation2021-01-21122 citations

10.1161/circulationaha.120.051542

Abstract 15545: Exercise-stress Real-time Cardiac Magnetic Resonance Imaging for Non-invasive Characterisation of Heart Failure With Preserved Ejection Fraction: The Hfpef Stress Trial

Soeren J Backhaus, Torben Lange, Elisabeth George, Kristian Hellenkamp, Roman Johannes Gertz et al. (15 authors)

Circulation2020-11-172 citations

10.1161/circ.142.suppl_3.15545

Interventions

DIAGNOSTIC_TESTstress CMR

additional stress CMR to the established clinical diagnostics

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* adult patients with dyspnoea under stress, echocardiographic criteria for diastolic dysfunction (E/E'\>8) and clinical indication for right heart catheterisation

Exclusion criteria

* arrhythmia (brady- or tachycardic) * bronchial asthma (allergic) * incompliant patient * pacemaker, ICD, non MRI-capable devices * inability to use the ergometer in the MRI * haemodynamic relevant valvular heart disease * pulmonary disease (vital capacity or forced expiratory flow \<80% of healthy control) * angina pectoris * post cardiac infarction * anaemia (Hb \<12 g/dl) * uncontrollable hypertension (\>150 mmHg systolic or \>100 mmHg diastolic) * age \<18 years * pregnancy * claustrophobia * renal insufficiency * allergic to gadolinium based contrast agents

Design outcomes

Primary

Measure	Time frame	Description
Cardiovascular magnetic resonance imaging	approx. 1 years	ventricular and atrial volumes

Other

Measure	Time frame	Description
Exercise spirometry	approx. 1 years	maximal oxygen uptake
Right heart catheterization	approx. 1 years	reference for intracardiac pressures: pulmonary artery pressure and pulmonary capillary wedge pressure

Countries

Germany

Outcome results

None listed