Influence of Sevoflurane and Desflurane on Postoperative Sore Throat

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03259672

Enrollment

100

Registered

2017-08-24

Start date

2017-10-01

Completion date

2018-11-01

Last updated

2017-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip Arthroplasty

Keywords

intubation, pharyngitis, remifentanil

Brief summary

This investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of sevoflurane or desflurane.

Interventions

DRUGSevoflurane

Sevoflurane was used as a maintenance anesthetic agent.

DRUGDesflurane

Desflurane was used as a maintenance anesthetic agent.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* ASA I-III * Patients scheduled for general anesthesia with endotracheal intubation

Exclusion criteria

* Difficult airway * Friable teeth * Rapid sequence induction * Recent sore throat * Recent upper respiratory infection * Asthma * Chronic obstructive pulmonary disease * Chronic cough * Arrhythmia * Coronary disease * Heart failure * Pregnancy * Allergy to sevoflurane * Allergy to desflurane * Fever after halogenated anesthetics * Jaundice after halogenated anesthetics * Malignant hyperthremia * Allergy to remifentanil * Friable teeth * History of head and neck surgery * Multiple intubation attempts * Regional anesthetic agents * Gastric tube * Dexamethasone * Severe hypovolemia

Design outcomes

Primary

Measure	Time frame
Number of participants with postoperative sore throat	At 24 hr

Secondary

Measure	Time frame
Number of participants with postoperative hoarseness	At 0, 2, 4 and 24 hr
Number of participants with postoperative cough	At 0, 2, 4 and 24 hr
Number of participants with postoperative nausea	At 0, 2, 4 and 24 hr
Number of participants with postoperative vomiting	At 0, 2, 4 and 24 hr
Number of participants with postoperative sore throat	At 0, 2, 4 and 24 hr
Visual analogue scale of postoperative pain	At 0, 2, 4 and 24 hr
Number of participants with shivering	At 0, 2, 4 and 24 hr
Requirements of analgesics	At 0, 2, 4 and 24 hr
Number of participants with additional pain medication	At 0, 2, 4 and 24 hr

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026