Simple Renal Cyst
Conditions
Keywords
Renal functional reserve, Simple renal cysts, Laparoscopic deroofing
Brief summary
Renal functional reserve may be improved in patients with simple renal cysts after laparoscopic deroofing.
Detailed description
Simple renal cysts (SRC) are the most frequent type of cystic renal disease. The prevalence rate of SRCs is about 10% and increases with age. Hypertension and decreased renal functions have been reported to occur more commonly among these patients with SRC and there are no clear guidelines for managing asymptomatic SRCs.Renal functional reserve (RFR) describes the capacity of the intact nephron mass to increase glomerular filtration rate(GFR) from baseline in response to stimuli (e.g., protein load).The investigators hypothesized that RFR may be improved in some patients with simple renal cysts after laparoscopic deroofing despite identical resting glomerular filtration rate (rGFR).The aim of this study is to examine whether there is improvement of RFR in patients with simple renal cysts after laparoscopic deroofing.
Interventions
PROCEDURELaparoscopic deroofing
The classic treatment of patients with simple renal cysts is deroofing, which can be performed by open surgery or laparoscopy. Laparoscopic deroofing is an effective minimally invasive approach and has gained popularity.
DRUG100 g of amino acids supplementation
intravenous supplementation with 100 g of amino acids 2 day before laparoscopic deroofing.
Sponsors
ou tongwen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants are assigned to two groups.One group participants are with endophytic simple renal cysts, and the other are with exophytic simple renal cysts.
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. Age ≥18 2. Estimated GFR \>30 mL/min/1.73m2 3. Subjects who signed informed consent forms
Exclusion criteria
1. Allergy to iothalamate, shellfish or iodine 2. Use of metformin or amiodarone 3. Inability to maintain a stable regimen of medications which affect GFR for \> one week prior to participation (e.g. non-steroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors, angiotensin receptor blockers) 4. Use of medications which directly affect elimination of creatinine (e.g. cimetidine and trimethoprim) 5. Acute exacerbation of asthma or chronic obstructive pulmonary disease within 3 months requiring hospitalization or oral steroid therapy 6. Inadequate intravenous access 7. Severe anemia (Hct \<21%) 8. Acute kidney injury (rise in creatinine to ≥1.5 times the previous baseline or by ≥ 0.3 mg/dL on most recent labs prior to enrollment) 9. History of contrast-induced nephropathy 10. Hyperthyroidism 11. Pheochromocytoma 12. Sickle cell disease 13. Urinary retention or incontinence 14. Status post organ transplant 15. Pregnancy or active breast feeding 16. Cognitive impairment with inability to give consent 17. Institutionalized status
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in renal functional reserve after laparoscopic deroofing | 1 month after surgery. | 1 month after surgery, repeated glomerular filtration rate measurements are to be performed to calculate change in renal functional reserve. |
Countries
China
Contacts
Primary ContactZhenhua Shang, MD.
Backup ContactHao Yan, MD.
Outcome results
None listed